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New treatment option for Asthma
Official title Evaluation of 3D Magnetic Resonance Spirometry: Comparison with Spirometry in Healthy Subjects and Patients with Respiratory Pathologies (asthma, COPD, Bilateral Lung Transplant)
ClinicalTrials.gov ID: NCT05724745
What this study is testing
What is 3. Reversibility test with salbutamol?
3. Reversibility test with salbutamol is an investigational medicine, given as an inhaled treatment, being studied as a potential treatment for asthma.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Spirometry is now the gold standard technique for assessing lung function in humans. From the shape of a flow-volume curve measured while the patient, trained by the practitioner, performs forced breaths, the forced vital capacity (FVC) and the forced expiratory volume in one second (FEV1) can be deduced and the pulmonologist is able to detect and characterize respiratory diseases as well as to evaluate current treatments.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 90. Healthy volunteers may be eligible.
You may be able to join if
- Generic Ability to understand the nature and objectives of the study
- Ability to remain immobile in an MRI scanner in supine position for the entire duration of the acquisitions
- Ability to give free and informed written consent Specific for healthy volunteers
- Age: 18-45 years
- No known and diagnosed pulmonary pathology such as respiratory insufficiency, COPD, asthma or cancer
See the full eligibility criteria
- Generic Ability to understand the nature and objectives of the study
- Ability to remain immobile in an MRI scanner in supine position for the entire duration of the acquisitions
- Ability to give free and informed written consent Specific for healthy volunteers
- Age: 18-45 years
- No known and diagnosed pulmonary pathology such as respiratory insufficiency, COPD, asthma or cancer
- Ability to remain motionless in an MRI scanner in a prone position for a total of 50 min.
- Non-smoker and non-smoker Specific for asthma patients
- Age: 18-80 years
- Asthma of varying degrees of severity, depending on inhalation required to achieve control:
- Diagnosis of asthma classified as moderate according to the Global initiative for asthma (GINA) guidelines for at least 6 months
- Diagnosis of asthma classified as severe according to the Global initiative for asthma (GINA) guidelines for at least 6 months months with initiation of biotherapy planned by their pulmonologist
- Non-smoker and non-vapourist Specific for COPD patients
- Age: 40-80 years
- COPD of varying degrees of severity:
- Diagnosis of COPD classified as moderate according to the Global initiative for chronic obstructive lung disease guidelines (GOLD 2: VEMS = 50-79%)
- Diagnosis of COPD classified as severe according to the guidelines for chronic obstructive lung disease (GOLD 3: VEMS = 30-49%) Specific for patients with bilateral lung transplants with BOS
- Age: 18-90 years
- Irreversible FEV1 \< 80% of baseline with FEV1/FVC ratio FEV1/FVC \< 0.7
- Absence of visible parenchymal opacity on CT scan (non inclusion of mixed RAS/CLAD)
- Absence of significant bronchial stenosis (having required endoscopic endoscopic treatment)
- No diaphragmatic involvement (established by sniff test under fluoroscopy fluoroscopy or diaphragmatic ultrasound) Specific for patients with bilateral lung transplants without BOS
- Age: 18-90 years
- FEV1 \> 90% baseline for more than 24 months after the date of date of lung transplantation
- Absence of significant bronchial stenosis (requiring endoscopic endoscopic treatment)
- Absence of diaphragmatic impairment (established by sniff test under fluoroscopy or diaphragmatic ultrasound)
The study team makes the final eligibility decision.
Where it's taking place
- Orsay, France, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 90 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Orsay, France, France. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.