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New treatment option for Heart Failure With Preserved Ejection Fraction
Official title Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF
ClinicalTrials.gov ID: NCT05723679
What this study is testing
- What it's testing
- The overall purpose of this study is to investigate whether pulmonary limitations that increase the oxygen (O2) cost of breathing impact dyspnea on exertion (DOE) and peak exercise capacity in patients with HFpEF and obesity. As per investigator's hypothesis, obesity is likely a significant contributor to DOE and exercise intolerance in patients with HFpEF.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 55 to 90. Healthy volunteers may be eligible.
You may be able to join if
- signs and symptoms of heart failure
- an ejection fraction \> 0.50;
- objective evidence of diastolic dysfunction. elevated biomarkers (NT-proBNP \>300 ng/dl) or HF hospitalization
- healthy volunteers
You likely can't join if
- age \< 55 years
- BMI \> 50 kg/m2
- Atrial fibrillation with poorly controlled heart rate
- phosphodiesterase type 5 (PDE5) inhibitor use
- severe valvular disease
- severe Chronic obstructive pulmonary disease (COPD)
See the full eligibility criteria
- signs and symptoms of heart failure
- an ejection fraction \> 0.50;
- objective evidence of diastolic dysfunction. elevated biomarkers (NT-proBNP \>300 ng/dl) or HF hospitalization
- healthy volunteers
- age \< 55 years
- BMI \> 50 kg/m2
- Atrial fibrillation with poorly controlled heart rate
- phosphodiesterase type 5 (PDE5) inhibitor use
- severe valvular disease
- severe Chronic obstructive pulmonary disease (COPD)
- Chronic kidney disease (CKD) 4 or higher
- any restriction of ambulation and mobility.
The study team makes the final eligibility decision.
Where it's taking place
- Dallas, Texas, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 55 years to 90 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Dallas, Texas, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.