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New treatment option for Bacteremia
Official title Reducing Risk for Infective Endocarditis
ClinicalTrials.gov ID: NCT05721781
What this study is testing
- What it's testing
- This clinical trial is studying if bacteria found in a participant's bloodstream after brushing their teeth can be prevented with a dental cleaning and more education on how to best brush and care for their teeth. One group of participants will have a dental cleaning and oral health instructions and the other group of participants will not.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- Age 18 years or older.
- Greater than 6 months since last dental hygiene prophylaxis (cleaning).
- 10 or more accessible teeth (including implants, with a minimum of 8 natural teeth).
- Willing and able to provide informed consent.
- Willing to comply with all study procedures and be available for the duration of the study.
You likely can't join if
- At high risk for IE, as defined by the 2007/2021 AHA Guidelines:
- Prosthetic cardiac valve or prosthetic material used for cardiac valve repair.
- Previous episode of IE.
- Cardiac transplantation recipient with cardiac valvulopathy.
- Specific congenital heart disease conditions.
- Pregnant, by self-report, or planning to become pregnant during the study period.
See the full eligibility criteria
- Age 18 years or older.
- Greater than 6 months since last dental hygiene prophylaxis (cleaning).
- 10 or more accessible teeth (including implants, with a minimum of 8 natural teeth).
- Willing and able to provide informed consent.
- Willing to comply with all study procedures and be available for the duration of the study.
- Willing to forgo routine professional dental cleanings while enrolled in the trial.
- At high risk for IE, as defined by the 2007/2021 AHA Guidelines:
- Prosthetic cardiac valve or prosthetic material used for cardiac valve repair.
- Previous episode of IE.
- Cardiac transplantation recipient with cardiac valvulopathy.
- Specific congenital heart disease conditions.
- Pregnant, by self-report, or planning to become pregnant during the study period.
- Affected by a condition that, in the opinion of the investigator, may preclude them from study completion or put them at increased risk such as :
- Hemodialysis dependent.
- Have a long-term intravascular catheter (e.g., for chemotherapy or parenteral nutrition).
- Active injection drug use (IDU).
- Clotting disorder such as, hemophilia.
- Have a solid organ transplant or hematopoietic stem cell transplant, or ongoing treatment for hematologic cancer.
- Currently incarcerated.
- Systemic antibiotic use within the past 2 weeks.
- Undergoing orthodontic treatment with fixed appliances (brackets and wires) or plans to do so during the study period.
- Taking or requiring antibiotic prophylaxis prior to dental procedures for other reasons, e.g., to prevent prosthetic joint infection .
- Three or more teeth with moderate to severe gingival hyperplasia.
- Has clinically detectable emergent or urgent dental needs that, in the trained and calibrated Oral Examiner's opinion, would require definitive dental care during the study period.
The study team makes the final eligibility decision.
Where it's taking place
- Boston, Massachusetts, United States
- Ann Arbor, Michigan, United States
- Newark, New Jersey, United States
- New York, New York, United States
- Rochester, New York, United States
- Charlotte, North Carolina, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Boston, Massachusetts, United States; Ann Arbor, Michigan, United States; Newark, New Jersey, United States; New York, New York, United States; Rochester, New York, United States; Charlotte, North Carolina, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.