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New treatment option for Depression in Adolescence
Official title Neuro-affective Response to Light in Depressed Adolescents and Young Adults
ClinicalTrials.gov ID: NCT05712772
What this study is testing
- What it's testing
- The goal of this neuroimaging pilot study is to understand developmental differences in the impact of therapeutic wavelength light (blue light) versus a non-therapeutic wavelength (red light) on emotional brain function in depression. The main questions this study aims to answer are: Does acute exposure to blue light (vs red light) stabilize emotional brain function in depressed individuals?
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 12 to 30
You may be able to join if
- Elevated Depressive Symptoms [PHQ9≥5 And (Item 1≥1 or Item 2≥1)]
- (If \<18yr) Parent or guardian can attend the baseline clinical interview
You likely can't join if
- Unable to read and write in English
- Intellectual disability.
- Left or mixed handedness
- Changes to psychotropic medication type or dosage in the past 2 months
- Lifetime bipolar disorder or schizophrenia, or substance/alcohol disorder in the past 3 months.
- Factors influencing light and color sensitivity (i.e., color-blindness, serious ophthalmological conditions, photo-sensitizing medication).
See the full eligibility criteria
- Elevated Depressive Symptoms [PHQ9≥5 And (Item 1≥1 or Item 2≥1)]
- (If \<18yr) Parent or guardian can attend the baseline clinical interview
- Unable to read and write in English
- Intellectual disability.
- Left or mixed handedness
- Changes to psychotropic medication type or dosage in the past 2 months
- Lifetime bipolar disorder or schizophrenia, or substance/alcohol disorder in the past 3 months.
- Factors influencing light and color sensitivity (i.e., color-blindness, serious ophthalmological conditions, photo-sensitizing medication).
- Factors influencing the ability to maintain a stable sleep schedule (i.e., shift work, severe sleep disorders, extremely late or early sleep schedule).
- Severe medical illness, neurological disorders, or history of head trauma.
- Current pregnancy or nursing
- MRI contraindication (e.g., metals in the body, recent tattoo, claustrophobia)
- Positive alcohol or substance use screen at MRI visit
The study team makes the final eligibility decision.
Where it's taking place
- Pittsburgh, Pennsylvania, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 12 years to 30 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Pittsburgh, Pennsylvania, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.