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New treatment option for Mild Cognitive Impairment
Official title Improvement of Memory in Mild Cognitive Impairment
ClinicalTrials.gov ID: NCT05708001
What this study is testing
- What it's testing
- The Clinical Trial will systematically examine the feasibility of remote, caregiver-led tACS for older adults with memory deficits and evaluate whether repeated tACS leads to sustained improvement of neuronal activity and memory functions.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 55 to 85. Healthy volunteers may be eligible.
You may be able to join if
- Mild Cognitive Impairment (MCI) patients
- age ≥ 55 years old
- clinical diagnosis of mild cognitive impairment (MCI) based on a comprehensive clinical assessment and standard neuropsychological examination...
- confirmation of diagnosis will be made by Prof. Paul Unschuld, the study MD, based on a participant's cognitive evaluation and history
- understanding of the informed consent
You likely can't join if
- Mild Cognitive Impairment (MCI) patients
- age \< 55 years old
- any current diagnosis of a psychiatric disorder (e.g., schizophrenia, bipolar disorder, depressive disorder)
- other than MCI, any history of other progressive or genetic neurologic disorder (e.g., Parkinson's disease, multiple sclerosis, tubular sclerosis) or...
- history of head trauma resulting in prolonged loss of consciousness
- current history of poorly controlled headaches including chronic medication for migraine prevention
See the full eligibility criteria
- Mild Cognitive Impairment (MCI) patients
- age ≥ 55 years old
- clinical diagnosis of mild cognitive impairment (MCI) based on a comprehensive clinical assessment and standard neuropsychological examination including tests of language, visuospatial thinking, executive functions, and...
- confirmation of diagnosis will be made by Prof. Paul Unschuld, the study MD, based on a participant's cognitive evaluation and history
- understanding of the informed consent
- able and willing to comply with all study requirements
- informed consent form was signed
- women of childbearing potential (WOCBP) must perform a pregnancy test during screening Caregiver
- minimum 21 years of age
- self-reported computer/tablet proficiency
- willingness to learn how to use tACS
- availability during the study period to administer tACS to the participant
- informed consent form was signed
- women of childbearing potential (WOCBP) must perform a pregnancy test during screening
- Mild Cognitive Impairment (MCI) patients
- age \< 55 years old
- any current diagnosis of a psychiatric disorder (e.g., schizophrenia, bipolar disorder, depressive disorder)
- other than MCI, any history of other progressive or genetic neurologic disorder (e.g., Parkinson's disease, multiple sclerosis, tubular sclerosis) or acquired neurological disease (e.g., stroke, traumatic brain injury...
- history of head trauma resulting in prolonged loss of consciousness
- current history of poorly controlled headaches including chronic medication for migraine prevention
- history of fainting spells of unknown or undetermined etiology that might constitute seizures
- history of seizures, diagnosis of epilepsy
- any unstable medical condition or chronic uncontrolled medical conditions that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.)
- contraindication for undergoing MRI or receiving tACS
- any metal in the brain or skull (excluding dental fillings) or elsewhere in the body unless cleared by the responsible covering MD (e.g., MRI compatible joint replacement)
- any skin problems, such as dermatitis, psoriasis, or eczema
- any electrically, magnetically, or mechanically activated implanted devices such as a pacemaker, intracranial electrodes, implanted defibrillators, medication pumps, nerve stimulators, vascular clips, or any other...
- any serious life-threatening disease such as congestive heart failure, pulmonary obstructive chronic disease, or active neoplasia
- pregnant women
- adults lacking capacity for consent Caregiver
- insufficient understanding of study procedures
- poor eyesight, severe arthritis in the hands, pain, deformity or other condition that interferes with successful administration of tACS
The study team makes the final eligibility decision.
Where it's taking place
- Geneva, Switzerland
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 55 years to 85 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Geneva, Switzerland. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.