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New treatment option for Extramedullary Myeloma
Official title CAR-T Cell Therapy in RelApsed/Refractory Myeloma With ExtrameduLlary Disease - an in Vivo Imaging and Molecular Monitoring Study
ClinicalTrials.gov ID: NCT05666700
What this study is testing
What is Combination Product: JNJ-68284528 (Cilta-cel) & 64Cu SPION dual PET-MR imaging agent?
Combination Product: JNJ-68284528 (Cilta-cel) & 64Cu SPION dual PET-MR imaging agent is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for extramedullary myeloma.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This clinical trial will investigate the in vivo trafficking of cilta-cel in extramedullary myeloma using 64Cu Super Paramagnetic Iron Oxide Nanoparticle (64Cu SPION) and Positron Emission Tomography-Magnetic Resonance Imaging (PET-MRI)
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Patients must meet all the following criteria for study entry:
- Patient has provided written informed consent
- Patient is \>18 years of age at the time of consent
- Patient has a documented diagnosis of MM according to the IMWG diagnostic criteria (Appendix 1)
- Measurable extramedullary disease by any imaging modality (at least one site of disease ≥1cm that has never received radiotherapy or has progressed...
You likely can't join if
- (e.g., contraceptive requirements) Exclusion Criteria: Patients who meet any of the following criteria will be excluded from study entry:
- Known nickel or Pd sensitivity
- Weight \>105 Kg and/or height \>185 cm
- Known claustrophobia
- Prior treatment with CAR-T therapy directed at any target
- Received a cumulative dose of corticosteroids equivalent to ≥70mg of prednisone within the 7 days prior to planned apheresis
See the full eligibility criteria
Who can join
- Patients must meet all the following criteria for study entry:
- Patient has provided written informed consent
- Patient is \>18 years of age at the time of consent
- Patient has a documented diagnosis of MM according to the IMWG diagnostic criteria (Appendix 1)
- Measurable extramedullary disease by any imaging modality (at least one site of disease ≥1cm that has never received radiotherapy or has progressed following radiotherapy). Presence of biochemical measurable disease is...
- Have received at least 2 prior lines of therapy including a PTI and an IMiD. Patient must have undergone at least 1 complete cycle of treatment for each line of therapy, unless PD was the best response to the line of...
- Have an ECOG Performance Status score of 0 or 1 (Appendix 3)
- Have a life expectancy of ≥3 months, as judged by the Investigator
- Able to undergo apheresis for mononuclear cell collection
- Have clinical laboratory values meeting the following criteria within 7 days prior to registration (enrolment):
- Haemoglobin ≥80g/L (recombinant human erythropoietin use is permitted)
- ANC ≥1 × 109/L (prior growth factor support is permitted but must be without support in the 7 days prior to the laboratory test)
- Platelet count ≥50 × 109/L
- Absolute lymphocyte count ≥0.3 × 109/L
- AST ≤3.0× ULN
- ALT ≤3.0× ULN
- Total bilirubin ≤2.0× ULN; except in patients with congenital bilirubinaemia, such as Gilbert's syndrome (in which case direct bilirubin ≤2.0× ULN is required)
- Calculated CrCl ≥40mL/min calculated by the Cockcroft-Gault formula (Appendix 4), nuclear medicine assessment or a 24-hour urine collection
- When a woman is of childbearing potential, the patient must commit either to abstaining continuously from heterosexual intercourse or agree to practice 2 methods of reliable birth control simultaneously. Where one of...
- User-independent methods: 1) implantable progestogen-only hormone contraception associated with inhibition of ovulation; 2) intrauterine device; intrauterine hormone-releasing system; 3) vasectomised partner
- User-dependent method: progestogen-only hormone contraception associated with inhibition of ovulation (oral or injectable)
- A man must commit either to abstaining continuously from heterosexual intercourse or a man who is sexually active with a WOCBP or a pregnant woman must agree to use a barrier method of contraception (e.g., latex or...
- Women and men must agree not to donate eggs (ova, oocytes) or sperm, respectively, until at least 1 year after receiving a cilta-cel infusion
- Patient must be willing and able to adhere to the following lifestyle restrictions during the study to be eligible for participation:
- Refer to Section 8.6.3, Prohibited Therapies for details regarding prohibited and restricted therapy during the study
- Agree to follow all requirements that must be met during the study as noted in the Inclusion and
What rules you out
- (e.g., contraceptive requirements) Exclusion Criteria: Patients who meet any of the following criteria will be excluded from study entry:
- Known nickel or Pd sensitivity
- Weight \>105 Kg and/or height \>185 cm
- Known claustrophobia
- Prior treatment with CAR-T therapy directed at any target
- Received a cumulative dose of corticosteroids equivalent to ≥70mg of prednisone within the 7 days prior to planned apheresis
- Any prior therapy that is targeted to BCMA
- Vaccination with an investigational vaccine or live attenuated vaccine (except for COVID-19) within 4 weeks prior to planned conditioning
- Patient received any anti-tumour therapy as follows, prior to planned apheresis:
- Targeted therapy, epigenetic therapy, or treatment with an investigational drug or use of an invasive investigational medical device within 14 days or at least 5 half-lives, whichever is less
- Investigational vaccine within 4 weeks
- Monoclonal antibody treatment within 21 days
- Cytotoxic therapy within 14 days
- Radiotherapy within 14 days. However, if the radiation is given for palliative purposes and the radiation portal covered ≤5% of the bone marrow reserve, the patient is eligible irrespective of the end date of...
- Active malignancies (i.e., progressing or requiring treatment change in the last 24 months) other than the disease being treated under study. The only allowed exceptions are:
- Non-muscle invasive bladder cancer treated within the last 24 months that is considered completely cured
- Skin cancer (non-melanoma or melanoma) treated within the last 24 months that is considered completely cured
- Non-invasive cervical cancer treated within the last 24 months that is considered completely cured
- Localised prostate cancer (N0M0):
- With a Gleason score of ≤6, treated within the last 24 months or untreated and under surveillance
- With a Gleason score of 3+4 that has been treated more than 6 months prior to full study screening and considered to have a very low risk of recurrence, or
- History of localised prostate cancer and receiving androgen deprivation therapy and considered to have a very low risk of recurrence
- Breast cancer: adequately treated lobular carcinoma in situ or ductal carcinoma in situ, or history of localised breast cancer and receiving anti-hormonal agents and considered to have a very low risk of recurrence
- Malignancy that is considered cured with minimal risk of recurrence
- Plasma cell leukaemia at the time of screening (\>2.0 x 109/L plasma cells by standard differential), Waldenström's macroglobulinaemia, POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein...
- Contraindications or known life-threatening allergies, hypersensitivity, or intolerance to any of the study treatments (if known) or any of their excipients, including boron, mannitol, and dimethyl sulfoxide (refer to...
- Pregnant or breast-feeding or planning to become pregnant while enrolled in this study or within 1 year after receiving cilta-cel infusion
- Plans to father a child while enrolled in this study or within 1 year after receiving cilta-cel infusion
- Stroke or seizure within 6 months prior to signing PICF
- Received either of the following:
- An allogenic stem cell transplant within 6 months before planned apheresis. Patients who received an allogeneic transplant must have stopped all immunosuppressive medications for 6 weeks without signs of...
- An ASCT ≤12 weeks before planned apheresis
- Known active, or prior history of, CNS involvement or exhibits clinical signs of meningeal involvement of MM
- Any of the following criterion related to infectious diseases:
- Seropositive for HIV
- Hepatitis B infection: In the event the infection status is unclear, quantitative viral levels are necessary to determine the infection status (Appendix 6)
- Hepatitis C infection (defined as anti -HCV antibody positive or HCV-RNA positive) or known to have a history of hepatitis C NOTE: For patients with positive HCV antibody due to prior resolved disease can be enrolled...
- Serious underlying medical or psychiatric condition or disease, that is likely to interfere with study procedures or results, or that in the opinion of the Investigator would constitute a hazard for participating in...
- Requirement of continuous supplemental oxygen
- Evidence of active viral or bacterial infection, requiring systemic antimicrobial therapy, or uncontrolled systemic fungal infection
- Active autoimmune disease
- Overt clinical evidence of dementia or altered mental status
- Any history of Parkinson's disease or other neurodegenerative disorder
- Clinically significant cardiac conditions, such as:
- NYHA Class III or IV congestive heart failure (Appendix 7) Short title: CARAMEL Page 60 of 128 Version: 1.0 Date: 17th November 2022
- Myocardial infarction or coronary-artery-bypass graft ≤6 months prior to planned apheresis
- History of clinically significant ventricular arrhythmia or unexplained syncope, not believed to be vasovagal in nature or due to dehydration
- History of severe non-ischemic cardiomyopathy
- Impaired cardiac function (LVEF \<45%) as assessed by ECHO or MUGA scan performed ≤8 weeks before planned apheresis
- Major operations or surgical procedures within 2 weeks prior to bridging therapy, or has surgery planned during the study or within 2 weeks after study treatment administration Note: patients with planned surgical...
- Frailty index of ≥ 2 according to Myeloma Geriatric Assessment score (Appendix 8)
- Any issue that would impair the ability of the patient to receive or tolerate the planned treatment, to understand informed consent or any condition for which, in the opinion of the Investigator, participation would not...
The study team makes the final eligibility decision.
Where it's taking place
- Melbourne, Victoria, Australia
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Melbourne, Victoria, Australia. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.