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New treatment option for Mild Cognitive Impairment
Official title Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity
ClinicalTrials.gov ID: NCT05655325
What this study is testing
- What it's testing
- The purpose of this study is to see if 6 months of home-based walking will improve memory, and brain structure and function, compared to health education in older adults that have chronic kidney disease and mild cognitive impairment.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 55 and older
You may be able to join if
- Diagnosed stage 3-4 chronic kidney disease (CKD, estimated glomerular filtration rate (eGFR) \<60 to 20 ml/min);
- \>55 yrs of age
- Mild cognitive impairment (18-26 on the MOCA)
- ability to undergo an MR
- no history of major head trauma (No head trauma/concussion with loss of consciousness)
You likely can't join if
- Diagnosed Dementia or a Clinical Dementia Rating Scale score of \<2, or a MOCA of \<18
- Participating in a supervised exercise program with intent to increase fitness levels 3 days/week,
- Requires assistive ambulation
- Limited exercise capacity due to claudication; unstable angina, severe arthritis, extreme dyspnea on exertion, unstable coronary artery disease
- Class III-IV heart failure
- History of uncontrolled sustained arrhythmias, severe/symptomatic aortic or mitral stenosis, hypertrophic obstructive cardiomyopathy, severe...
See the full eligibility criteria
- Diagnosed stage 3-4 chronic kidney disease (CKD, estimated glomerular filtration rate (eGFR) \<60 to 20 ml/min);
- \>55 yrs of age
- Mild cognitive impairment (18-26 on the MOCA)
- ability to undergo an MR
- no history of major head trauma (No head trauma/concussion with loss of consciousness)
- Speaks, reads, writes English
- Diagnosed Dementia or a Clinical Dementia Rating Scale score of \<2, or a MOCA of \<18
- Participating in a supervised exercise program with intent to increase fitness levels 3 days/week,
- Requires assistive ambulation
- Limited exercise capacity due to claudication; unstable angina, severe arthritis, extreme dyspnea on exertion, unstable coronary artery disease
- Class III-IV heart failure
- History of uncontrolled sustained arrhythmias, severe/symptomatic aortic or mitral stenosis, hypertrophic obstructive cardiomyopathy, severe pulmonary hypertension, active myocarditis/pericarditis, thrombophlebitis, and...
- Resting systolic BP \>200 mmHg or resting diastolic BP \>110 mmHg
- Any unforeseen illness or disability that would preclude cognitive testing or exercise training
- One or more contraindication for MRI; cardiac pacemaker, aneurysm clip, cochlear implants, shrapnel, history of metal fragments in eyes, neurostimulators, diagnosed claustrophobia (MRI only)
- Any self-reported major psychiatric disorders requiring medical therapy (e.g. schizophrenia, bipolar disorder).
- Self-reported new diagnosis of clinical depression within 3 months of enrollment or unstable clinical depression requiring medication adjustment within 3 months of enrollment
The study team makes the final eligibility decision.
Where it's taking place
- New York, New York, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 55 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include New York, New York, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.