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New treatment option for Respiratory Insufficiency
Official title Feasibility of Reducing Respiratory Drive Using the Through-flow System
ClinicalTrials.gov ID: NCT05642832
What this study is testing
- What it's testing
- Mechanical ventilation can lead to diaphragm and lung injury. During mechanical ventilation, the diaphragm could be completely rested or it could be overworked, either of which may cause diaphragm injury.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- PaO2/FiO2 less than or equal to 300 at time of screening
- Oral endotracheal intubation with ETT 7.5 or 8.0 and on invasive mechanical ventilation
- Bilateral airspace opacities on chest radiograph or chest CT scan
You likely can't join if
- Contraindication to esophageal catheterization (upper gastrointestinal tract surgery within preceding 6 weeks, bleeding esophageal/gastric varices)
- Intubation for traumatic brain injury or stroke
- Intracranial hypertension (suspected or diagnosed by medical team)
- Anticipated liberation from mechanical ventilation within 24 hours
The study team makes the final eligibility decision.
Where it's taking place
- Toronto, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Toronto, Ontario, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.