BridgeMD
New treatment option for Frailty
Official title Effects of Low-dose Esmolol on Myocardial Injury After Non-cardiac Surgery in Elderly Frail Patients
ClinicalTrials.gov ID: NCT05635877
What this study is testing
What is Esmolol?
Esmolol is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for frailty.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This topic will focus on the following questions: 1. Part one: To clarify the relationship between preoperative frailty and myocardial injury (cTnT ≥0.03) after non-cardiac surgery in elderly patients; To further explore the predictive factors of myocardial injury after non-cardiac surgery （MINS） in elderly frail patients before operation.
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 65 to 90
You may be able to join if
- Age ≥ 65 years;
- ASA: ⅰ-ⅳ;
- Modified frailty index (mFI) ≥ 0.21;
- Patients undergoing non-cardiac surgery.
You likely can't join if
- Refuse to participate;
- Expected hospital stay \<3 days;
- Preoperative β-blocker therapy;
- History of myocardial infarction or coronary artery disease;
- Preoperative bradycardia (heart rate [HR] \< 50 bpm) or arrhythmia;
- Significant cardiac insufficiency (i.e., pulmonary artery pressure \>18 mm Hg, cardiac index ≤ 2.2 L/min/m 2);
See the full eligibility criteria
- Age ≥ 65 years;
- ASA: ⅰ-ⅳ;
- Modified frailty index (mFI) ≥ 0.21;
- Patients undergoing non-cardiac surgery.
- Refuse to participate;
- Expected hospital stay \<3 days;
- Preoperative β-blocker therapy;
- History of myocardial infarction or coronary artery disease;
- Preoperative bradycardia (heart rate [HR] \< 50 bpm) or arrhythmia;
- Significant cardiac insufficiency (i.e., pulmonary artery pressure \>18 mm Hg, cardiac index ≤ 2.2 L/min/m 2);
- Severe valvular heart disease;
- Severe lung disease (e.g. asthma or chronic obstructive pulmonary disease);
- Patients with perioperative troponin elevation due to nonischemic causes (e.g., sepsis, pulmonary embolism, arrhythmia);
- The same patient can only be included once, regardless of whether the reason for the second operation is related to the first cause. \-
The study team makes the final eligibility decision.
Where it's taking place
- Jinan, Shandong, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65 years to 90 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Jinan, Shandong, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.