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Tests treatment safety and results for Severe Dengue
Official title Efficacy of Dengue Infection With Warning Signs Treated With Dexamethasone (DengDex Study)
ClinicalTrials.gov ID: NCT05631405
What this study is testing
What is Dexamethasone?
Dexamethasone is an investigational medicine, being studied as a potential treatment for severe dengue.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The goal of this randomized double-blinded placebo-controlled trial is to learn about dexamethasone and the treatment of severe dengue population. The main question it aims to answer are steroid therapy may be effective in dengue.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 7 to 99
You may be able to join if
- Laboratory confirmed Dengue infected patients (Positive NS1 Ag or anti-DENV IgM by Dengue Duo test)
- And still in febrile phase (Body temp\>37.5 C)
- Shock : Sys\ 100/min) with Hematocrit decreased ≥20 %
- Fluid accumulation and respiratory distress
- Severe bleeding
You likely can't join if
- Severe dengue\> 24 hrs
- Dengue without warning signs
- Pregnancy
- Patient who receieved any steroid within 1 week
See the full eligibility criteria
- Laboratory confirmed Dengue infected patients (Positive NS1 Ag or anti-DENV IgM by Dengue Duo test)
- And still in febrile phase (Body temp\>37.5 C)
- Shock : Sys\ 100/min) with Hematocrit decreased ≥20 %
- Fluid accumulation and respiratory distress
- Severe bleeding
- Severe organ involvement
- Severe dengue\> 24 hrs
- Dengue without warning signs
- Pregnancy
- Patient who receieved any steroid within 1 week
The study team makes the final eligibility decision.
Where it's taking place
- Bangkok, Thailand
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 7 years to 99 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Bangkok, Thailand. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.