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New treatment option for Depression in Adolescence
Official title Mindfulness-Based fMRI Neurofeedback for Depression
ClinicalTrials.gov ID: NCT05617495
What this study is testing
- What it's testing
- In the United States, adolescents experience alarmingly high rates of major depression, and gold-standard treatments are only effective for approximately half of patients. Rumination may be a promising treatment target, as it is well-characterized at the neural level and contributes to depression onset, maintenance, and recurrence as well as predicts treatment non-response.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 13 to 18
You may be able to join if
- Ages 13-18 years-old
- Written informed assent/consent and parental/guardian permission for 13-17 year-olds or informed consent for 18 year-olds
- Tanner puberty stage ≥3
- Meets current diagnostic criteria for MDD
- English fluency
You likely can't join if
- Lifetime history of primary psychotic disorders, bipolar disorder, oppositional defiant disorder, conduct disorder, developmental disorder (e.g...
- Substance use disorder, moderate or severe in past 6 months
- Active suicidal ideation with a specific plan
- History of seizure disorder
- Medical or neurological illness (e.g., severe head injury)
- MRI contraindications
See the full eligibility criteria
- Ages 13-18 years-old
- Written informed assent/consent and parental/guardian permission for 13-17 year-olds or informed consent for 18 year-olds
- Tanner puberty stage ≥3
- Meets current diagnostic criteria for MDD
- English fluency
- Lifetime history of primary psychotic disorders, bipolar disorder, oppositional defiant disorder, conduct disorder, developmental disorder (e.g., autism), post-traumatic stress disorder, or eating disorders
- Substance use disorder, moderate or severe in past 6 months
- Active suicidal ideation with a specific plan
- History of seizure disorder
- Medical or neurological illness (e.g., severe head injury)
- MRI contraindications
- Current psychotropic medication use other than antidepressant medication
- Intelligence quotient (IQ) \<80.
The study team makes the final eligibility decision.
Where it's taking place
- Boston, Massachusetts, United States
- New York, New York, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 13 years to 18 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Boston, Massachusetts, United States; New York, New York, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.