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New treatment option for Lung Metastases
Official title In Vivo Lung Perfusion (IVLP) for Colorectal Cancer Metastatic to Lung
ClinicalTrials.gov ID: NCT05611034
What this study is testing
What is Oxaliplatin?
Oxaliplatin is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for lung metastases.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is investigating a new technique for delivering chemotherapy directly into the lungs at the time of surgery. Delivering chemotherapy directly to the lungs could potentially kill any microscopic cancer cells that are present in the lungs at the time of surgery, while sparing other major organs in the body from the side effects of chemotherapy.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 70
You may be able to join if
- Diagnosis of Colorectal Carcinoma
- Presence of bilateral pulmonary metastases
- 3 or more lung lesions in total
- Age 70 years or less
- ECOG 0-2
You likely can't join if
- Patient has previously received more than 1000 mg of oxaliplatin
- Left Ventricular Ejection Fraction \<50%
- History of significant pulmonary disease or pneumonitis
- Pregnant or lactating females
- Age 71 or older, or less than 18 years
- Inability to understand the informed consent process
See the full eligibility criteria
- Diagnosis of Colorectal Carcinoma
- Presence of bilateral pulmonary metastases
- 3 or more lung lesions in total
- Age 70 years or less
- ECOG 0-2
- Absence of extra-pulmonary disease, except liver metastases suitable to curative treatment.
- Patient has previously received more than 1000 mg of oxaliplatin
- Left Ventricular Ejection Fraction \<50%
- History of significant pulmonary disease or pneumonitis
- Pregnant or lactating females
- Age 71 or older, or less than 18 years
- Inability to understand the informed consent process
- Hypersenstivity to oxaliplatin
- Patients with Heparin-induced thrombocytopenia (HIT)
- Patients who cannot receive cefazolin or methylprednisolone due to allergy or another reason can be included but will not receive the drug they cannot tolerate
- Current participation in another therapeutic clinical trial
The study team makes the final eligibility decision.
Where it's taking place
- Toronto, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 70 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Toronto, Ontario, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.