BridgeMD
New treatment option for Type 2 Diabetes
Official title Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction
ClinicalTrials.gov ID: NCT05593549
What this study is testing
What is Trehalose?
Trehalose is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for type 2 diabetes.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The goal of this clinical trial is to examine the role of autophagy on microvascular function in adults with Type 2 Diabetes. The main question it aims to answer are: Does presence of Type 2 Diabetes reduce autophagy and impair microvascular function?
- Phase 1: an early, usually small safety study
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 80. Healthy volunteers may be eligible.
You may be able to join if
- Participants must be between 18-80 yrs. of age and will be delineated into two groups
- Clinical Diagnosis of Type 2 Diabetes Mellitus in accordance with American Diabetes Association (ADA) guidelines (Type 2 Diabetic group)
- Otherwise healthy individuals (Healthy control group) with no more than 1 cardiovascular risk factor
You likely can't join if
- Uncontrolled hypertension
- Current Tobacco use or within last 6 months
- BMI \> 35
- Hyperlipidemia
- Hypercholesterolemia
- Type 1 Diabetes
See the full eligibility criteria
- Participants must be between 18-80 yrs. of age and will be delineated into two groups
- Clinical Diagnosis of Type 2 Diabetes Mellitus in accordance with American Diabetes Association (ADA) guidelines (Type 2 Diabetic group)
- Otherwise healthy individuals (Healthy control group) with no more than 1 cardiovascular risk factor
- Uncontrolled hypertension
- Current Tobacco use or within last 6 months
- BMI \> 35
- Hyperlipidemia
- Hypercholesterolemia
- Type 1 Diabetes
- Use of anti-coagulant drugs, or anti-platelet drugs
- Symptomatic coronary artery disease
- Heart Failure
- Renal Impairment
- Hormone Replacement Therapy
- History of Retinopathy
- Documented Neuromuscular Disorders
- Porphyria Cutanea Tarda (blistering of skin to sun; photosensitivity)
- Pregnancy (Young Female people)
- Allergies to Povidone Iodine
- Use Erectile Dysfunction Medication in the past 6 months
- Use of Topical/non-topical Steroids in last 6 months
- Active Anti-Cancer Treatment or Treatment within last 12 months
- Active COVID-19 or within the past 3 months
- Gender Reassignment Therapy
The study team makes the final eligibility decision.
Where it's taking place
- Milwaukee, Wisconsin, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 80 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Milwaukee, Wisconsin, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.