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Compares treatment options for Upper GI Bleeding
Official title PPI Infusion Versus Oral Acid Pump Inhibitors for Bleeding Peptic Ulcers
ClinicalTrials.gov ID: NCT05582174
What this study is testing
What is Vonoprazan?
Vonoprazan is an investigational medicine, given as an once-daily infusion into a vein, being studied as a potential treatment for upper gi bleeding.
Also referred to as Takecab.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Vonoprazan (VPZ), an oral potassium-competitive acid blocker (P-CAB) has emerged as an alternative potent acid-suppressant.It has a faster onset of action in 1 day (3-5 days in PPI), and is more stable in acidic condition than PPI. While many studies compared Vonoprazan against PPI in the treatment of reflux oesophagitis, H.
- Phase 4: studies an already-approved treatment
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- \- Patients aged ≥18 years who had undergone oesophagogastroduodenoscopy (OGD) for sign and symptoms of aneamia or upper GI bleeding including...
- Major stigmata of recent haemorrhage includes peptic ulcers with spurting or oozing bleeding (Forrest classification Ia and Ib, respectively) ,with a...
- Patients who had undergone endoscopic hemostatic treatment (a combination of hemoclipping therapy or contact thermocoagulation using...
You likely can't join if
- No consent
- Patients under the age of 18
- Patients who were pregnant or in lactation
- Hypersensitivity to PPI or Vonoprazan or any component of the formulation
- Patients who were found to have tumour bleeding, oesophageal varices as the cause of the NVGIB
- NVGIB due to post therapeutic endoscopic treatment such as gastric polypectomy, endoscopic mucosal resection, endoscopic submucosal dissection etc.
The study team makes the final eligibility decision.
Where it's taking place
- Guangzhou, Guangdong, China
- Shenzhen, Guangdong, China
- Yangjiang, Guangdong, China
- Zhuhai, Guangdong, China
- Hong Kong, Hong Kong SAR, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Guangzhou, Guangdong, China; Shenzhen, Guangdong, China; Yangjiang, Guangdong, China; Zhuhai, Guangdong, China; Hong Kong, Hong Kong SAR, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.