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Official title Studying the Hedonic and Homeostatic Regulation of Food Intake Using Functional MRI
ClinicalTrials.gov ID: NCT05525845
What this study is testing
- What it's testing
- The purpose of this study is to investigate how gut hormones and brain areas respond differently to gastric distention, tasteless calories, or palatable food and how this alters appetite.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 21 to 50. Healthy volunteers may be eligible.
You may be able to join if
- BMI 18-25 kg/m\^2.
- Weight stable for 3 months prior to study entry.
- For females: study days will be scheduled during the follicular phase of their menstrual cycle (i.e., the first 13 days (about 2 weeks) of the cycle).
- Able to provide written informed consent prior to any study procedures and be willing and able to follow study procedures..
- Ability to perform light to moderate physical activity.
You likely can't join if
- Any contraindication for MRI scanning.
- Any history of childhood (\> 95th percentile) or adult obesity (BMI \>30 kg/m\^2).
- Claustrophobia.
- High intensity training or physical activity.
- Any contraindication for intragastric balloon insertion.
- Any allergies to the study meals.
See the full eligibility criteria
- BMI 18-25 kg/m\^2.
- Weight stable for 3 months prior to study entry.
- For females: study days will be scheduled during the follicular phase of their menstrual cycle (i.e., the first 13 days (about 2 weeks) of the cycle).
- Able to provide written informed consent prior to any study procedures and be willing and able to follow study procedures..
- Ability to perform light to moderate physical activity.
- Any contraindication for MRI scanning.
- Any history of childhood (\> 95th percentile) or adult obesity (BMI \>30 kg/m\^2).
- Claustrophobia.
- High intensity training or physical activity.
- Any contraindication for intragastric balloon insertion.
- Any allergies to the study meals.
- Any history of eating disorder.
- Any substance abuse disorder (including alcohol and tobacco).
- Any history of psychiatric disorders.
- Any cardiovascular, endocrine, pulmonary, neurological, or gastrointestinal comorbidities.
- Pregnancy or nursing.
- Any history of bariatric surgery or endoscopic bariatric procedure.
- Use of any medication or supplement that alters appetite.
- Patient has a known history of any condition or factor judged by the investigator to prevent participation in the study or which might hinder study adherence.
The study team makes the final eligibility decision.
Where it's taking place
- Rochester, Minnesota, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 21 years to 50 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Rochester, Minnesota, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.