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New treatment option for Lung Diseases
Official title Comparison of Two Strategies of One-lung Ventilation in Patients Undergoing Carcinological Lung Resection Surgery.
ClinicalTrials.gov ID: NCT05525312
What this study is testing
- What it's testing
- During thoracic surgery, one-lung ventilation (OLV) is associated with hypoxemia, lung injury, and perioperative respiratory complications. The level of positive-end expiratory pressure (PEEP) to apply during OLV remains controversial.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- To be over 18 years old,
- To be able to attend all scheduled visits and to comply with all trial procedures,
- To be scheduled for a lung cancer resection surgery (performed by either video-assisted thoracoscopy or thoracotomy).
You likely can't join if
- Non-carcinologic indication of lung resection (e.g. Lung volume reduction for bullous emphysema reduction, lung abscess),
- Bilateral pulmonary resection surgery or history of lung resection surgery,
- Lung resection under sternotomy
- Non intubated video-assisted thoracoscopy
- Robotic thoracic surgery
- Contraindication to esophageal catheter (history of esophageal varices, hepatic cirrhosis child ≥ b, esophageal or gastric surgery, thoracic...
See the full eligibility criteria
- To be over 18 years old,
- To be able to attend all scheduled visits and to comply with all trial procedures,
- To be scheduled for a lung cancer resection surgery (performed by either video-assisted thoracoscopy or thoracotomy).
- Non-carcinologic indication of lung resection (e.g. Lung volume reduction for bullous emphysema reduction, lung abscess),
- Bilateral pulmonary resection surgery or history of lung resection surgery,
- Lung resection under sternotomy
- Non intubated video-assisted thoracoscopy
- Robotic thoracic surgery
- Contraindication to esophageal catheter (history of esophageal varices, hepatic cirrhosis child ≥ b, esophageal or gastric surgery, thoracic radiotherapy, latex allergy),
- ASA (American Society of Anesthesiologists) score ≥ 4,
- Chronic obstructive pulmonary disease GOLD III or IV (Forced Expiratory Volume, FEV\<50%),
- Uncontrolled asthma (FEV \<50%),
- Intracardiac shunt,
- Hemoglobinopathy making the SpO2 values invalid,
- Heart failure NYHA III or IV,
- Documented pulmonary hypertension (Mean Pulmonary Arterial Pressure at rest, mPAP\>20 mmHg),
- To be under legal protection,
- Unable to read or write,
- Lack of informed consent, or unable to give consent,
- Refusal to participate in the study,
- Pregnancy in progress or planned during the study period, pregnant or nursing women,
- Not being affiliated to a French social security system or being a beneficiary of such a system.
The study team makes the final eligibility decision.
Where it's taking place
- Montpellier, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Montpellier, France. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.