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New treatment option for Multiple Sclerosis
Official title MRI Biomarkers Predictive of Disability Progression in Patients With Multiple Sclerosis
ClinicalTrials.gov ID: NCT05491031
What this study is testing
- What it's testing
- The transition from relapsing-remitting multiple sclerosis to secondarily progressive multiple sclerosis (SPMS) is difficult to identify. Typically, SPMS is diagnosed retrospectively, with a significant delay, on the basis of a clinical history of progressive worsening, independent of relapses.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥ 18 years,
- Duration of disease ≤ 25 years,
- Irreversible disability ≤ 7 (permanent wheelchair use) on the EDSS scale
You likely can't join if
- Other progressive neurological disease,
- Isolated radiologic syndrome (RIS),
- Severe psychiatric pathology not in balance,
- Change in dosage, discontinuation or initiation of a psychotropic treatment within the last month,
- Change in background MS treatment for less than 3 months,
- A course of corticosteroids (oral or intravenous) for less than one month,
See the full eligibility criteria
- Age ≥ 18 years,
- Duration of disease ≤ 25 years,
- Irreversible disability ≤ 7 (permanent wheelchair use) on the EDSS scale
- Other progressive neurological disease,
- Isolated radiologic syndrome (RIS),
- Severe psychiatric pathology not in balance,
- Change in dosage, discontinuation or initiation of a psychotropic treatment within the last month,
- Change in background MS treatment for less than 3 months,
- A course of corticosteroids (oral or intravenous) for less than one month,
- Patient with a contraindication to MRI: pregnancy, metallic ocular foreign body (accidental splinters or others), pacemaker, implantable defibrillator, neurostimulator not compatible with MRI 7.0 T, cochlear implants...
- Illiterate and non-French speaking patient: patient who is partially or completely unable to read and write French.
- Patient benefiting from reinforced protection, i.e. minor, subject deprived of liberty by a judicial or administrative decision, subject staying in a health or social establishment, adult under legal protection and...
- Pregnant or breastfeeding women, women of childbearing age who do not have effective contraception (hormonal/mechanical: per os, injectable, transcutaneous, implantable, intrauterine device, or surgical: tubal ligation...
The study team makes the final eligibility decision.
Where it's taking place
- Poitiers, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Poitiers, France. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.