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New treatment option for Ischemic Stroke, Acute
Official title Effects of Minocycline on Patients With Ischemic Stroke Undergoing Intravenous Thrombectomy
ClinicalTrials.gov ID: NCT05487417
What this study is testing
What is Minocycline?
Minocycline is an investigational medicine, being studied as a potential treatment for ischemic stroke, acute.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Minocycline is the second generation of tetracycline. Because of its lipophilicity, it has high penetrance of blood-brain barrier.
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 85
You may be able to join if
- Patients with acute cerebral infarction of anterior circulation accompanied by large vessel occlusion;
- Age 18-85 years old;
- The time of onset ≤ 6 hours or ≤ 24 hours suitable for mechanical thrombectomy determined by multimodal imaging;
- The time of onset 6-24 hours, DWI shows an infarct volume less than 1/3 of the MCA blood supply area; the time of onset ≤ 6 hours, the...
- Preoperative NIHSS score ranges from 6 to 30 points;
You likely can't join if
- There are contraindications for mechanical thrombectomy;
- No revascularization therapy was performed during the operation or the TICI score after revascularization therapy was less than 2b;
- There are other major central nervous system diseases, such as brain injury, brain tumor, multiple sclerosis, etc;
- There is evidence that the patient has bacterial endocarditis, aortic dissection, arteritis or venous cerebral infarction;
- Renal insufficiency or hepatic insufficiency (serum creatinine \>2.0 mg/dL or 180 µmol/L; liver function greater than 3 times the normal value);
- Known history of congestive heart failure (requiring dietary or medication changes or hospitalization) within 6 months, or myocardial infarction...
See the full eligibility criteria
- Patients with acute cerebral infarction of anterior circulation accompanied by large vessel occlusion;
- Age 18-85 years old;
- The time of onset ≤ 6 hours or ≤ 24 hours suitable for mechanical thrombectomy determined by multimodal imaging;
- The time of onset 6-24 hours, DWI shows an infarct volume less than 1/3 of the MCA blood supply area; the time of onset ≤ 6 hours, the ASPECTS(Alberta Stroke Program Early CT Score) is ≥6;
- Preoperative NIHSS score ranges from 6 to 30 points;
- Sign the informed consent form;
- There are contraindications for mechanical thrombectomy;
- No revascularization therapy was performed during the operation or the TICI score after revascularization therapy was less than 2b;
- There are other major central nervous system diseases, such as brain injury, brain tumor, multiple sclerosis, etc;
- There is evidence that the patient has bacterial endocarditis, aortic dissection, arteritis or venous cerebral infarction;
- Renal insufficiency or hepatic insufficiency (serum creatinine \>2.0 mg/dL or 180 µmol/L; liver function greater than 3 times the normal value);
- Known history of congestive heart failure (requiring dietary or medication changes or hospitalization) within 6 months, or myocardial infarction within 6 months;
- There is evidence of any other life-threatening or severe diseases that may hinder the completion of the 3-month follow-up and affect the evaluation of the results;
- Pre-existing neurological deficits or history of dementia;
- There are infectious diseases that require antibiotic treatment before the disease;
- Allergic to tetracyclines or unable to take minocycline for other reasons;
- Minocycline could not be given within 1 hour after recanalization;
- Pregnant patients;
- Participated in another clinical trial within 30 days before inclusion in the study.
- Refuse to sign the informed consent form.
The study team makes the final eligibility decision.
Where it's taking place
- Xi'an, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 85 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Xi'an, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.