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New treatment option for Cardiac Arrest, Out-Of-Hospital
Official title CardioPulmonary Resuscitation With Argon (CPAr) Trial
ClinicalTrials.gov ID: NCT05482945
What this study is testing
What is Noble gas Argon?
Noble gas Argon is an investigational medicine, being studied as a potential treatment for cardiac arrest, out-of-hospital.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Preclinical studies suggest that argon (Ar) might diminish the neurological and myocardial damage after any hypoxic-ischemic insult. Indeed, Ar has been tested in different models of ischemic insult, at concentrations ranging from 20% up to 80%.
- Phase 2: a mid-size study of how well it works
- Time commitment: about 6 months
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- ICU admission after resuscitation from witnessed non-traumatic out-of-hospital cardiac arrest (OHCA) of presumably cardiac etiology with a presenting...
- age ≥ 18 years;
- unconsciousness after return of spontaneous circulation (ROSC);
- duration of CPR ≤ 40 mins;
- initiation of study intervention ≤ 4 hrs from ROSC;
You likely can't join if
- Non-witnessed CA;
- CA of traumatic origin or from a non-presumably cardiac cause;
- CA with a non-shockable presenting rhythm (pulseless electrical activity and asystole);
- female of childbearing potential defined as younger of 50 years;
- pregnancy;
- known terminal illness;
See the full eligibility criteria
- ICU admission after resuscitation from witnessed non-traumatic out-of-hospital cardiac arrest (OHCA) of presumably cardiac etiology with a presenting shockable rhythm;
- age ≥ 18 years;
- unconsciousness after return of spontaneous circulation (ROSC);
- duration of CPR ≤ 40 mins;
- initiation of study intervention ≤ 4 hrs from ROSC;
- stable SaO2 ≥ 94% with a FiO2 of 30%.
- Non-witnessed CA;
- CA of traumatic origin or from a non-presumably cardiac cause;
- CA with a non-shockable presenting rhythm (pulseless electrical activity and asystole);
- female of childbearing potential defined as younger of 50 years;
- pregnancy;
- known terminal illness;
- pre-CA cerebral performance category (CPC) ≥ 3;
- initiation of the study intervention \> 4 hrs from ROSC;
- participation to another clinical trial
The study team makes the final eligibility decision.
Where it's taking place
- Genova, GE, Italy
- Monza, MB, Italy
- Milan, Milan, Italy
- Parma, Parma, Italy
- Pordenone, Pordenone, Italy
- Reggio Emilia, Reggio Emilia, Italy
- Roma, RM, Italy
- Trento, Trento, Italy
- Trieste, TS, Italy
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The study runs about 6 months per participant, based on its public description. The team confirms the exact schedule and number of visits before you enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Genova, GE, Italy; Monza, MB, Italy; Milan, Milan, Italy; Parma, Parma, Italy; Pordenone, Pordenone, Italy; Reggio Emilia, Reggio Emilia, Italy and 3 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.