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New treatment option for Pulmonary Arterial Hypertension
Official title PET Image in PAH Patients
ClinicalTrials.gov ID: NCT05452889
What this study is testing
What is (18F)FPGLU?
(18F)FPGLU is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for pulmonary arterial hypertension.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Pulmonary arterial hypertension (PAH) is mortal disease affecting the blood vessels of the lung. Despite its morbid prognosis, PAH is often misdiagnosed or ignored, with an average time of 44 months between onset of symptoms to diagnosis and substantial progression of disease severity.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 75. Healthy volunteers may be eligible.
You may be able to join if
- Cases:
- Age between 18-75 years old
- Confirmed diagnosis of SSc-PAH / SSc-eiPAH/IPAH/ by right heart catheterization. And Scleroderma with no PAH confirmand by echo. Controls:
- Age between 18-75 years old
- Individuals who are at low risk for current or future cardiovascular or pulmonary symptoms or diseases
You likely can't join if
- Cases:
- Smoking
- Pregnant/ breast feeding women
- Children under 18
- Inability to read and understand the informed consent
- History of CT contrast allergy
See the full eligibility criteria
- Cases:
- Age between 18-75 years old
- Confirmed diagnosis of SSc-PAH / SSc-eiPAH/IPAH/ by right heart catheterization. And Scleroderma with no PAH confirmand by echo. Controls:
- Age between 18-75 years old
- Individuals who are at low risk for current or future cardiovascular or pulmonary symptoms or diseases
- Cases:
- Smoking
- Pregnant/ breast feeding women
- Children under 18
- Inability to read and understand the informed consent
- History of CT contrast allergy
- Inability to lie down for long period of time
- Having claustrophobic
- History of radiation exposure at workplace
- Consuming more than 2-3 alcoholic drinks a week
- Working previously in any of the following "cool miner, painter, iron miner, Mill worker, asbestos, insulation/heat resistance materials, sand"
- Any medical conditions involving the heart or lungs that would make participation in the study unsafe in the opinion of the PI. Controls:
- Smoking
- Pregnant/ breast feeding women
- Children under 18
- Inability to read and understand the informed consent
- History of CT contrast allergy.
- Inability to lie down for long period of time
- Having claustrophobic
- History of radiation exposure at workplace
- Consuming more than 2-3 alcoholic drinks a week
- Working previously in any of the following "coal miner, painter, iron miner, Mill worker, asbestos, insulation/heat resistance materials, sand"
- Any medical conditions involving the heart or lungs or that would make participation in the study unsafe in the opinion of the PI.
- Family history of Pulmonary Hypertension or Scleroderma
The study team makes the final eligibility decision.
Where it's taking place
- Pittsburgh, Pennsylvania, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 75 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Pittsburgh, Pennsylvania, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.