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New treatment option for Mild Cognitive Impairment
Official title Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History
ClinicalTrials.gov ID: NCT05446584
What this study is testing
- What it's testing
- This study will probe if the biological changes in amnestic mild cognitive impairment (aMCI) are related to a history of mild traumatic brain injury (mTBI) using high definition transcranial direct current stimulation (HD-tDCS) and blood-derived biomarker tools. Participants who Do as well as those who Do Not have a history of mTBI will be enrolled in the study.
- Phase 2: a mid-size study of how well it works
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 55 and older
You may be able to join if
- Active diagnosis of amnestic mild cognitive impairment
- Presence of an mTBI history for the mTBI+ group; absence of an mTBI history for a control sample
- Female and male people
- All races/ethnicities
- Age 55 years and older
You likely can't join if
- Mild traumatic brain injury within past year
- Lifetime history of moderate or severe brain injury
- Lifetime major neurologic syndromes (e.g., stroke, epilepsy, brain tumor)
- Lifetime major cardiovascular conditions (e.g., heart attack, heart failure)
- Current substance use disorder
- Current major psychiatric disorders (e.g., major depressive disorder, bipolar disorder)
See the full eligibility criteria
- Active diagnosis of amnestic mild cognitive impairment
- Presence of an mTBI history for the mTBI+ group; absence of an mTBI history for a control sample
- Female and male people
- All races/ethnicities
- Age 55 years and older
- Fluent in English
- Mild traumatic brain injury within past year
- Lifetime history of moderate or severe brain injury
- Lifetime major neurologic syndromes (e.g., stroke, epilepsy, brain tumor)
- Lifetime major cardiovascular conditions (e.g., heart attack, heart failure)
- Current substance use disorder
- Current major psychiatric disorders (e.g., major depressive disorder, bipolar disorder)
- Current vision or hearing impairment that interferes with testing
- Any electronic and or metallic implants in the skull or brain
- Current medication use known to alter HD-tDCS reactivity
The study team makes the final eligibility decision.
Where it's taking place
- Dallas, Texas, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 55 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Dallas, Texas, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.