BridgeMD
New treatment option for Rumination
Official title Decoding and Modulating Affective Brain States
ClinicalTrials.gov ID: NCT05437705
What this study is testing
- What it's testing
- The research study is being conducted to study brain patterns of negative emotion and develop personalized brain stimulation protocols to disrupt these patterns with transcranial magnetic stimulation (TMS). First, the investigators will use functional Magnetic Resonance Imaging (fMRI) data to generate a negative affect map for each participant.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65
You may be able to join if
- 18-65 years old
- Patient Health Questionnaire (PHQ-9 score) = or \> than 10
- Comprehension of instructions in the English language.
- Capacity to provide informed consent and follow study procedures.
- Availability for the duration of the study.
You likely can't join if
- Diagnosis of bipolar disorder (as PI discretion), schizophrenia or other psychotic disorder
- Recent use of psychoactive medications or substances as determined by investigators
- History of neurological disorder or traumatic brain injury (other than mild)
- Unable to have an MRI scan, or current or prior medical condition that could interfere with the collection or interpretation of MRI data
- Unable to receive or tolerate TMS
- Implanted devices, such as an aneurysm clip or cardiac pacemaker
See the full eligibility criteria
- 18-65 years old
- Patient Health Questionnaire (PHQ-9 score) = or \> than 10
- Comprehension of instructions in the English language.
- Capacity to provide informed consent and follow study procedures.
- Availability for the duration of the study.
- Diagnosis of bipolar disorder (as PI discretion), schizophrenia or other psychotic disorder
- Recent use of psychoactive medications or substances as determined by investigators
- History of neurological disorder or traumatic brain injury (other than mild)
- Unable to have an MRI scan, or current or prior medical condition that could interfere with the collection or interpretation of MRI data
- Unable to receive or tolerate TMS
- Implanted devices, such as an aneurysm clip or cardiac pacemaker
- History of stroke, epilepsy, or brain scarring
- Pregnant, nursing, or trying to become pregnant (self-attestation alone) During this study, participants are asked to:
- Refrain from substance use (including marijuana and illicit drugs) for duration of the study (self-attestation alone).
- Abstain from alcohol for 24 hours before the MRI scans (self-attestation alone).
- Abstain from increasing caffeine intake or begin taking any new medications (self-attestation alone).
The study team makes the final eligibility decision.
Where it's taking place
- Philadelphia, Pennsylvania, United States
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Philadelphia, Pennsylvania, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.