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New treatment option for Glaucoma
Official title Metformin as a Neuroprotective Therapy for Glaucoma
ClinicalTrials.gov ID: NCT05426044
What this study is testing
What is Metformin?
Metformin is an investigational medicine, given as an once-daily pill taken by mouth, being studied as a potential treatment for glaucoma.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Glaucoma, a chronic degenerative disease of the optic nerve, is the leading cause of irreversible blindness worldwide. Although lowering the intraocular pressure (IOP) has been shown to be effective to slow optic nerve degeneration, a significant portion of glaucoma patients continue to develop progressive loss in vision despite adequate control of IOP.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- age ≥18 years
- best corrected VA ≥20/40
- IOP ≤24mmHg at the screening and baseline visits
- progressive RNFL and/or GCIPL thinning by TPA or GPA over the past 3 years in at least one eye.
You likely can't join if
- patients with DM, kidney or liver diseases
- pathological myopia
- cognitive impairment (e.g. Alzheimer's disease)
- diseases that may cause visual field loss or optic disc abnormalities other than glaucoma
- inability to perform reliable visual field
- suboptimal quality of OCT images. Both eyes of a patient will be included in the analysis if both eyesare eligible for inclusion.
The study team makes the final eligibility decision.
Where it's taking place
- Wong Chuk Hang, Hong Kong
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Wong Chuk Hang, Hong Kong. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.