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New treatment option for Muscle Atrophy
Official title Impacts of Mechanistic Target of Rapamycin (mTOR) Inhibition on Aged Human Muscle (Rapamune)
ClinicalTrials.gov ID: NCT05414292
What this study is testing
What is Rapamune (sirolimus) 1Mg Tablet?
Rapamune (sirolimus) 1Mg Tablet is an investigational medicine, given as an once-weekly pill taken by mouth, being studied as a potential treatment for muscle atrophy.
Also referred to as Rapamycin, Sirolimus.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- As people age, muscle mass and function is lost and exercise training is an important way to reduce the effects of this and remain independent. However, not everyone can perform this exercise and the muscle responses to exercise are often reduced in older people.
- You might receive a placebo (an inactive treatment) instead of the study drug. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 50 to 90, men only. Healthy volunteers may be eligible.
You may be able to join if
- Participant is willing and able to give informed consent for participation in the study
- Participant is physically able to complete the resistance exercise training programme
You likely can't join if
- A BMI \ 35 kg/m2
- Active cardiovascular, cerebrovascular or respiratory disease: e.g. uncontrolled hypertension (BP \> 160/100), angina, heart failure (class III/IV)...
- Any metabolic disease
- Clotting dysfunction
- A history of, or current neurological or musculoskeletal conditions (e.g. epilepsy)
- Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance (this must remain for ALL UoN...
See the full eligibility criteria
- Participant is willing and able to give informed consent for participation in the study
- Participant is physically able to complete the resistance exercise training programme
- A BMI \ 35 kg/m2
- Active cardiovascular, cerebrovascular or respiratory disease: e.g. uncontrolled hypertension (BP \> 160/100), angina, heart failure (class III/IV), arrhythmia, right to left cardiac shunt, recent cardiac event, COPD...
- Any metabolic disease
- Clotting dysfunction
- A history of, or current neurological or musculoskeletal conditions (e.g. epilepsy)
- Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance (this must remain for ALL UoN FMHS UREC approved studies)
- Contraindications to MRI scanning including claustrophobia, pacemaker, metal implants etc. which will be assessed through an MRI safety screening questionnaire.
- Contraindications to the use of Rapamycin e.g. those due scheduled vaccinations (as rapamycin can reduce the how well it works of vaccines).
The study team makes the final eligibility decision.
Where it's taking place
- Derby, United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling male, 50 years to 90 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Derby, United Kingdom. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.