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New treatment option for Volatile Organic Compounds
Official title Augmented Response of Volatile Biomarkers in Assessment of Oesophagogastric Cancer (AROMA 1 / BIORESOURCE)
ClinicalTrials.gov ID: NCT05412758
What this study is testing
- What it's testing
- Cancer of the stomach and oesophagus is among the world's top five cancers. Survival rates are very poor as the disease presents late and early symptoms are non-specific.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 90. Healthy volunteers may be eligible.
You may be able to join if
- AROMA 1
- Aged 18-90years
- Oesophageal/gastric cancer cohort: participants with biopsy proven adenocarcinoma who are treatment naïve
- Control cohort: participants with normal or benign upper gastrointestinal disease determined on: Endoscopy within 1 year Planned endoscopy AROMA 1
You likely can't join if
- Patients with the following characteristics will not be eligible for inclusion in this study:
- Oesophageal squamous cell carcinoma
- Previous oesophageal and gastric resection
- Received neoadjuvant chemotherapy for oesophageal or gastric cancer
- History of another cancer within three years
- Any form of oesophageal dysplasia (control cohort only)
See the full eligibility criteria
- AROMA 1
- Aged 18-90years
- Oesophageal/gastric cancer cohort: participants with biopsy proven adenocarcinoma who are treatment naïve
- Control cohort: participants with normal or benign upper gastrointestinal disease determined on: Endoscopy within 1 year Planned endoscopy AROMA 1
- Patients with the following characteristics will not be eligible for inclusion in this study:
- Oesophageal squamous cell carcinoma
- Previous oesophageal and gastric resection
- Received neoadjuvant chemotherapy for oesophageal or gastric cancer
- History of another cancer within three years
- Any form of oesophageal dysplasia (control cohort only)
- Previously diagnosed with Barrett's oesophagus (control cohort only)
- Active infection, on immunosuppressive medications or antibiotic therapy within the last 8 weeks
- Participants with co-morbidities preventing breath collection
- Allergies to any of the constituents of the nutrient drink including glucose, glycerol, iron sulphate, Maltodextrin (Corn, Potato), Xanthan Gum, Potassium Chloride, tyrosine, phenylalanine, and glutamic acid
- Unable or unwilling to provide informed written consent
- Pregnant participants BIORESOURCE inclusion criteria:
- Aged 18- 90years
- Oesophageal/gastric cancer cohort: participants with biopsy proven adenocarcinoma who are treatment naïve
- Oesophageal/gastric control cohort: participants with normal or benign upper gastrointestinal disease determined on: Planned endoscopy BIORESOURCE exclusion criteria:
- Oesophageal squamous cell carcinoma
- Previous oesophageal and gastric resection
- Received neoadjuvant chemotherapy for oesophageal or gastric cancer
- History of another cancer within five years
- Any form of oesophageal dysplasia (oesophageal/gastric control cohorts only)
- Previously diagnosed with Barrett's oesophagus (oesophageal/gastric control cohorts only)
- Active infection, on immunosuppressive medications or antibiotic therapy within the last 8 weeks
- Participants with co-morbidities preventing breath collection
- Unable or unwilling to provide informed written consent
- Pregnant participants
The study team makes the final eligibility decision.
Where it's taking place
- London, United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 90 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include London, United Kingdom. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.