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New treatment option for Parkinson Disease
Official title Blood Pressure Effects on Cognition and Brain Blood Flow in PD
ClinicalTrials.gov ID: NCT05400174
What this study is testing
- What it's testing
- Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide. Besides causing symptoms that impair movement, PD also causes non-motor symptoms, such as problems thinking and orthostatic hypotension (OH), i.e., low blood pressure (BP) when standing.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 50 and older
You may be able to join if
- Diagnosis of idiopathic Parkinson Disease using the Movement Disorders Society (MDS) Clinical Diagnostic Criteria
- Age at least 50 years old
- Hoehn \& Yahr (H\&Y) stages I-III (early to moderate-stage PD; able to walk without assistance
- Proficiency in the English language (native English speaker level)
You likely can't join if
- Any involuntary movements (i.e., tremor or dyskinesia) \> 3 cm in amplitude (ok if movements are treated with medication), since the motion artifact...
- Dementia (including PD dementia)
- History of deep brain stimulation (DBS) surgery
- Any current unstable, active medical problem, e.g. decompensated heart failure, liver failure, pneumonia, etc.
- Moderate or severe carotid artery stenosis (according to North American Symptomatic Carotid Endarterectomy Trial (NASCET) criteria
- History of cerebral infarction or hemorrhage
See the full eligibility criteria
- Diagnosis of idiopathic Parkinson Disease using the Movement Disorders Society (MDS) Clinical Diagnostic Criteria
- Age at least 50 years old
- Hoehn \& Yahr (H\&Y) stages I-III (early to moderate-stage PD; able to walk without assistance
- Proficiency in the English language (native English speaker level)
- Any involuntary movements (i.e., tremor or dyskinesia) \> 3 cm in amplitude (ok if movements are treated with medication), since the motion artifact could interfere with blood pressure monitor data collection
- Dementia (including PD dementia)
- History of deep brain stimulation (DBS) surgery
- Any current unstable, active medical problem, e.g. decompensated heart failure, liver failure, pneumonia, etc.
- Moderate or severe carotid artery stenosis (according to North American Symptomatic Carotid Endarterectomy Trial (NASCET) criteria
- History of cerebral infarction or hemorrhage
- Uncontrolled diabetes or any other systemic disease causing autonomic failure
- Syncope (fainting) within the past week
- Illiteracy (unable to read)
- Taking antihypertensive medications or alpha-adrenergic blocking medications, since these can cause hypotension (see \ below)
- Impairment of hearing or vision that is not corrected by devices (e.g., hearing aids or glasses)
- Currently pregnant (will be confirmed by women of child-bearing potential with a urine pregnancy test)
- Any other condition, which, in the opinion of the investigator, could place the participant at increased risk.
- Please note that persons may not participate if they are taking any of the following:
- medications to treat high blood pressure (called "antihypertensives") such as clonidine (Catapres), hydralazine, verapamil, diltiazem (Cartia), or medications ending in "-olol", "-artan", or "-pril")
- diuretics (also called "water pills") such as furosemide (Lasix), bumetanide (Bumex), hydrochlorothiazide (HCTZ; Microzide), or spironolactone (Aldactone)
- medications for enlarged prostate such as prazosin (Minipress), terazosin, doxazosin (Cardura), alfuzosin (Uroxatral), or tamsulosin (Flomax) If persons are taking these medications and would like to participate in the...
The study team makes the final eligibility decision.
Where it's taking place
- San Diego, California, United States
Compensation & support
A stipend or compensation may be offered.
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 50 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include San Diego, California, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.