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New treatment option for Liver Diseases
Official title Identification of Hepatic Fibrosis Using 4D-MRI
ClinicalTrials.gov ID: NCT05385237
What this study is testing
- What it's testing
- To date, no specific treatment options exist for liver diseases, and there is a large global effort to find drugs that will halt liver disease progression in these patients.Liver fibrosis staging is essential as a diagnostic/prognostic measure and there is an increasing demand for accurate non-invasive liver stiffness measurement tools. This research project proposes a novel MR-based quantitative Liver Deformation Biomarker (qLDB) approach for non-invasive liver fibrosis assessment by using a new technique called 4D-MRI.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- age ≥ 18 years
- (a) Patients with histologically confirmed chronic liver disease, including NAFLD, ALD, viral hepatitis B and C, genetic (e.g. Wilson disease...
- (b) Patients with acute liver inflammation or cardiac blood congestion to the liver (as assessed by laboratory values, imaging findings and clinical...
- ability to understand and consent to participate in this study
You likely can't join if
- Medical implant like cardiac pacemaker, pump, hip prosthesis
- Metallic objects in the body (e.g. splinters after an accident)
- Persons who have undergone brain or cardiac surgery
- Claustrophobia
- Body Weight \>140kg or as provided by the MR manufacturer
- Pregnant and lactating women
See the full eligibility criteria
- age ≥ 18 years
- (a) Patients with histologically confirmed chronic liver disease, including NAFLD, ALD, viral hepatitis B and C, genetic (e.g. Wilson disease, hemochromatosis) or autoimmune liver disease
- (b) Patients with acute liver inflammation or cardiac blood congestion to the liver (as assessed by laboratory values, imaging findings and clinical history)
- ability to understand and consent to participate in this study
- Medical implant like cardiac pacemaker, pump, hip prosthesis
- Metallic objects in the body (e.g. splinters after an accident)
- Persons who have undergone brain or cardiac surgery
- Claustrophobia
- Body Weight \>140kg or as provided by the MR manufacturer
- Pregnant and lactating women
- (a) Active hepatocellular carcinoma (HCC) (remark: patients with a history of HCC and curative treatment can be included)
- (a) CHILD C cirrhosis
- (a) and (b) Patients with overt ascites (except if they respond to diuretic treatment and the ascites resolves)
- (c) Metabolic syndrome, BMI \>30 kg/m2
- (c) Acute or chronic liver disease
- Patients not willing or able to give a written informed consent
The study team makes the final eligibility decision.
Where it's taking place
- Liestal, Basel-Landschaft, Switzerland
- Basel, Canton of Basel-City, Switzerland
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Liestal, Basel-Landschaft, Switzerland; Basel, Canton of Basel-City, Switzerland. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.