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New treatment option for Primary Aldosteronism
Official title Endoscopic Ultrasound-guided Radiofrequency Ablation in Primary Aldosteronism
ClinicalTrials.gov ID: NCT05368090
What this study is testing
- What it's testing
- In this study, the investigators will perform endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) treatment of left-sided adrenal tumours in patients with primary aldosteronism (PA) and in patients with mild autonomous cortisol secretion (MACS). Four different study groups will all receive EUS-RFA of left-sided adrenal tumours.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 80
You may be able to join if
- all groups
- Signed written informed consent
- If CT scan shows an adrenal nodule to the same adrenal as AVS lateralisation result: nodule size \ 40% or absolute wash-out \> 60%) PA unilateral...
- Age 18 to 60 years
- PA diagnosis confirmed according to Endocrine Society PA Guideline criteria
You likely can't join if
- all groups:
- CT scan suspicion of adrenal malignancy
- Patient refusal to undergo either EUS-RFA or adrenalectomy
See the full eligibility criteria
- all groups
- Signed written informed consent
- If CT scan shows an adrenal nodule to the same adrenal as AVS lateralisation result: nodule size \ 40% or absolute wash-out \> 60%) PA unilateral group
- Age 18 to 60 years
- PA diagnosis confirmed according to Endocrine Society PA Guideline criteria
- AVS lateralisation to left adrenal (lateralisation index ≥ 4,0) PA "debulking" group
- Age 18 to 70 years
- PA diagnosis confirmed according to Endocrine Society PA Guideline criteria MACS unilateral and debulking group
- Age 18 to 80 years
- MACS diagnosis confirmed according to ENSAT/ECE Guideline criteria
- AVS lateralisation to the left adrenal, and visible left adrenal tumor on CT scan OR bilateral overproduction of cortisol on AVS, and bilateral tumors/hyperplasia on CT scan (debulking)
- all groups:
- CT scan suspicion of adrenal malignancy
- Patient refusal to undergo either EUS-RFA or adrenalectomy
The study team makes the final eligibility decision.
Where it's taking place
- Bergen, Norway
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Bergen, Norway. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.