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New treatment option for Orthostatic Hypotension
Official title Hypercapnia in Orthostatic Hypotension
ClinicalTrials.gov ID: NCT05295810
What this study is testing
What is Sequential Gas Delivery?
Sequential Gas Delivery is an investigational medicine, given as an inhaled treatment, being studied as a potential treatment for orthostatic hypotension.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The Autonomic (or "automatic") Nervous System (ANS) regulates internal processes, including control of heart rate and blood pressure (BP). When someone stands, and gravity tries to pull blood away from the brain, the ANS works to maintain BP and brain blood flow.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 100. Healthy volunteers may be eligible.
You may be able to join if
- Age ≥18 years
- Male and Female
- Non - smokers.
- Able and willing to provide informed consent.
- Ability to travel to Libin Cardiovascular Institute Autonomic Testing Lab at the University of Calgary, Calgary, AB.
You likely can't join if
- Medical therapies or medications which could interfere with testing of autonomic function
- Participants with somatization or severe anxiety symptoms will be excluded
- Pregnant or breast-feeding females
- Inability to tolerate mask for the duration of the study
- people who require portable oxygen at rest or with exercise
- people with chronic heart failure or severe pulmonary disease who are unable to climb one flight of stairs due to shortness of breath.
See the full eligibility criteria
- Age ≥18 years
- Male and Female
- Non - smokers.
- Able and willing to provide informed consent.
- Ability to travel to Libin Cardiovascular Institute Autonomic Testing Lab at the University of Calgary, Calgary, AB.
- Medical therapies or medications which could interfere with testing of autonomic function
- Participants with somatization or severe anxiety symptoms will be excluded
- Pregnant or breast-feeding females
- Inability to tolerate mask for the duration of the study
- people who require portable oxygen at rest or with exercise
- people with chronic heart failure or severe pulmonary disease who are unable to climb one flight of stairs due to shortness of breath.
- Presence of failure of other organ systems or systemic illness that can affect autonomic function or the participant's ability to cooperate. These include: dementia, alcohol and/or drug abuse, cerebrovascular disease...
- Other factors which in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies.
The study team makes the final eligibility decision.
Where it's taking place
- Calgary, Alberta, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 100 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Calgary, Alberta, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.