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New treatment option for Cardiac Arrest
Official title Surviving PEA in Roanoke (SPEAR) Study
ClinicalTrials.gov ID: NCT05283850
What this study is testing
What is High Calcium, Low Sodium (HCLS) Crystalloid Therapy?
High Calcium, Low Sodium (HCLS) Crystalloid Therapy is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for cardiac arrest.
Also referred to as (NDC) National Drug Code NDC 0264-7800-00 and NDC 0409-4928-11.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The Carilion Clinic and Virginia Tech Carilion School of Medicine, in conjunction with Roanoke Fire-EMS, Botetourt County Department of Fire \& EMS and Salem Fire-EMS, are studying the outcomes of patients experiencing Pulseless Electrical Activity (PEA). PEA refers to a type of cardiac arrest in which there is normal electrical activity in the heart however the heart still fails to contract to generate a pulse.
- Phase 3: a large, late-stage study
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- All patients who present with PEA at any time during the patients' treatment by Roanoke Fire-EMS, Botetourt County Department of Fire \& EMS and/or...
You likely can't join if
- Patient less than 18 years old
- Known pregnancy
- Duration of untreated cardiac arrest of more than 30 minutes
- Traumatic cardiac arrest
- Known (LVAD) Left Ventricular Assist Device
- Rapidly fatal underlying disease
See the full eligibility criteria
- All patients who present with PEA at any time during the patients' treatment by Roanoke Fire-EMS, Botetourt County Department of Fire \& EMS and/or Salem Fire-EMS. This study defines a PEA presentation as any patient...
- Patient less than 18 years old
- Known pregnancy
- Duration of untreated cardiac arrest of more than 30 minutes
- Traumatic cardiac arrest
- Known (LVAD) Left Ventricular Assist Device
- Rapidly fatal underlying disease
- Known or suspected digitalis toxicity
- A physical, durable (DNR) Do Not Resuscitate (or durable DNR medical jewelry) presented to EMS before treatment with asserting a preference not to be enrolled
- Prisoners and other populations with involuntary consent
The study team makes the final eligibility decision.
Where it's taking place
- Roanoke, Virginia, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Roanoke, Virginia, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.