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New treatment option for Pulmonary Disease, Chronic Obstructive
Official title Trial to Determine Effective Aspirin Dose in COPD
ClinicalTrials.gov ID: NCT05265299
What this study is testing
What is Aspirin 81mg?
Aspirin 81mg is an investigational medicine, given as an once-daily pill taken by mouth, being studied as a potential treatment for pulmonary disease, chronic obstructive.
Also referred to as Acetylsalicylic acid.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States. Current treatments for COPD focus on inhaler therapies that do not address manifestations of the disease on other organ systems.
- Phase 3: a large, late-stage study
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 to 80
You may be able to join if
- Age ≥40 years
- Former smoker
- At least 10 pack-year smoking history
- Post-bronchodilator ratio of forced expiratory volume in 1 second to forced vital capacity (FEV1/FVC) \< 0.7
You likely can't join if
- History of myocardial infarction, percutaneous coronary intervention, or stroke
- Currently taking antiplatelet therapy (other than aspirin 81mg) or anticoagulant medication
- Contraindication to aspirin (including low platelet count, hematocrit \<25%, known aspirin-exacerbated respiratory disease, bleeding disorder...
- Oral corticosteroids within the past 6 weeks
- Currently taking immunosuppressant medication
- Active malignancy (other than non-melanoma skin cancer)
See the full eligibility criteria
- Age ≥40 years
- Former smoker
- At least 10 pack-year smoking history
- Post-bronchodilator ratio of forced expiratory volume in 1 second to forced vital capacity (FEV1/FVC) \< 0.7
- History of myocardial infarction, percutaneous coronary intervention, or stroke
- Currently taking antiplatelet therapy (other than aspirin 81mg) or anticoagulant medication
- Contraindication to aspirin (including low platelet count, hematocrit \<25%, known aspirin-exacerbated respiratory disease, bleeding disorder, history of bleeding or gastrointestinal (GI) ulcer, coagulopathy, or major...
- Oral corticosteroids within the past 6 weeks
- Currently taking immunosuppressant medication
- Active malignancy (other than non-melanoma skin cancer)
- Uncontrolled hypertension
- Pregnant or planning pregnancy in the next year
- Plans to move residence away from the immediate area within the next 3 months
The study team makes the final eligibility decision.
Where it's taking place
- Baltimore, Maryland, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Baltimore, Maryland, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.