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New treatment option for Mechanical Ventilation Complication
Official title Systolic Function and Weaning-induced Pulmonary Edema (SystoWean Study)
ClinicalTrials.gov ID: NCT05226247
What this study is testing
- What it's testing
- The purpose of this study is to determine if the left and right ventricular systolic function is involved in the development of weaning failure related to weaning-induced pulmonary edema.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Invasive mechanical ventilation for more than 48 hours
- Patients indicated, according to intensivists, for carrying out a spontaneous breathing trial weaning test, based on the presence of all of the...
- SpO2\> 90% with FiO2 ≤40% and PEEP ≤5 cmH2O
- Cough how well it works on tracheal aspirations
- Lack of hemodynamic instability and of disorders of consciousness
You likely can't join if
- Age \<18 years and pregnant women
- Patients with a decision of not to resuscitate
- Poor echogenicity
- Severe mitral valve disease (leakage and/or stenosis, bioprosthesis)
- Patients with pacemaker
- Tracheostomy
See the full eligibility criteria
- Invasive mechanical ventilation for more than 48 hours
- Patients indicated, according to intensivists, for carrying out a spontaneous breathing trial weaning test, based on the presence of all of the following criteria:
- SpO2\> 90% with FiO2 ≤40% and PEEP ≤5 cmH2O
- Cough how well it works on tracheal aspirations
- Lack of hemodynamic instability and of disorders of consciousness
- Patients at high risk of weaning-induced pulmonary edema (WIPO), defined by one or more of the following criteria:
- Obesity, defined by a body mass index\> 30 kg/m²
- Chronic obstructive pulmonary disease
- Chronic heart disease
- Age \<18 years and pregnant women
- Patients with a decision of not to resuscitate
- Poor echogenicity
- Severe mitral valve disease (leakage and/or stenosis, bioprosthesis)
- Patients with pacemaker
- Tracheostomy
- Chronic neuromuscular or neurodegenerative diseases
The study team makes the final eligibility decision.
Where it's taking place
- Dijon, France
- Nice, France
- Paris, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Dijon, France; Nice, France; Paris, France. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.