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New treatment option for Major Depressive Disorder
Official title Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression
ClinicalTrials.gov ID: NCT05194098
What this study is testing
- What it's testing
- Depression is a leading cause of morbidity and mortality, conferring substantial healthcare and societal costs. By studying methods to non-invasively target neural circuitry involved in reward responsivity, information generated by this project will improve understanding of the circuit alterations that underlie motivation and pleasure deficits in depression, and could also lead to the development of biologically-based markers of neurostimulation-based treatment response.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65. Healthy volunteers may be eligible.
You may be able to join if
- Our studies require some in-person visits to our research lab, located at 42nd Ave and Clement St in San Francisco.
- All participants
- 18-65 years old
- Normal (or corrected to normal) vision
- Participants with MDD
You likely can't join if
- (all participants):
- Premorbid IQ estimate \< 70
- Past or present neurological problems (including seizures and head trauma resulting in neurological or cognitive sequelae)
- Loss of consciousness \> 30 minutes or any loss of consciousness with neurological sequelae
- Major medical conditions (e.g., seizure disorders, treatment with anticonvulsant medication, endocrine disorders, significant cardiac pathology), or...
- Substance dependence, within the past year, current (past 3 months) substance misuse, or failed urine toxicology on the day of neuroimaging sessions
See the full eligibility criteria
- Our studies require some in-person visits to our research lab, located at 42nd Ave and Clement St in San Francisco.
- All participants
- 18-65 years old
- Normal (or corrected to normal) vision
- Participants with MDD
- Meet the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for MDD
- Screened for TMS and MRI safety
- On a stable psychiatric medication regime for \> 1 month
- (all participants):
- Premorbid IQ estimate \< 70
- Past or present neurological problems (including seizures and head trauma resulting in neurological or cognitive sequelae)
- Loss of consciousness \> 30 minutes or any loss of consciousness with neurological sequelae
- Major medical conditions (e.g., seizure disorders, treatment with anticonvulsant medication, endocrine disorders, significant cardiac pathology), or other physical conditions if they preclude participation in EEG, TMS...
- Substance dependence, within the past year, current (past 3 months) substance misuse, or failed urine toxicology on the day of neuroimaging sessions
- Known claustrophobia
- Pregnancy (a pregnancy urine test will be conducted to rule-out pregnancy) Exclusion criteria (Participants with MDD only)
- Past or present DSM-5 (SCID-5) 'Schizophrenia Spectrum or Other Psychotic Disorder' diagnosis
- Past or present DSM-5 (SCID-5) Bipolar and Related Disorders Diagnosis
- Past or present DSM-5 (SCID-5) MDD with psychotic features (mood congruent or mood incongruent)
- Past or present DSM-5 (SCID-5) Gambling Disorder Exclusion Criteria (HCs only)
- DSM-5 (SCID-5) criteria for any psychiatric disorder
The study team makes the final eligibility decision.
Where it's taking place
- San Francisco, California, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include San Francisco, California, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.