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Prevention study for Dexmedetomidine
Official title Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium in Elderly Patients
ClinicalTrials.gov ID: NCT05168280
What this study is testing
What is Dexmedetomidine?
Dexmedetomidine is an investigational medicine, being studied as a potential treatment for dexmedetomidine.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Postoperative delirium (POD) is a common surgical complication. The incidence is 10% to 22% in neurological procedures, and advanced age is a risk factor for neurological procedures.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 65 and older
You may be able to join if
- Patients undergoing selective craniotomy.
- Age ≥65 years.
- Obtain written informed consent.
You likely can't join if
- Operation time less than 2 hours.
- Refusal to provide written informed consent.
- Cognitive impairment before surgery(mini-mental state examination, MMSE ≤ 26 or Montreal Cognitive Assessment, MoCA≤22).
- Allergic to the study drug.
- Body mass index ≤18 or ≥ 30 kg/m2.
- History of psychotropic drugs, anticholinergic drugs, antihistamine drug and dopaminergic drugs.
See the full eligibility criteria
- Patients undergoing selective craniotomy.
- Age ≥65 years.
- Obtain written informed consent.
- Operation time less than 2 hours.
- Refusal to provide written informed consent.
- Cognitive impairment before surgery(mini-mental state examination, MMSE ≤ 26 or Montreal Cognitive Assessment, MoCA≤22).
- Allergic to the study drug.
- Body mass index ≤18 or ≥ 30 kg/m2.
- History of psychotropic drugs, anticholinergic drugs, antihistamine drug and dopaminergic drugs.
- History of traumatic brain injury or neurosurgery.
- Severe bradycardia (heart rate less than 40 beats per minute), sick sinus syndrome or second-to-third degree atrioventricular block.
- Severe liver dysfunction (Child-Pugh grade C) or renal failure (requiring kidney replacement therapy).
- The functional neurosurgery.
The study team makes the final eligibility decision.
Where it's taking place
- Beijing, Beijing Municipality, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Beijing, Beijing Municipality, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.