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New treatment option for Prodromal Schizophrenia
Official title Effects of NAC on Symptoms of CHR Patients
ClinicalTrials.gov ID: NCT05142735
What this study is testing
- What it's testing
- Schizophrenia is a chronic debilitating psychotic disorder. Identifying persons with "clinical high-risk" (CHR) symptoms, which are like those of schizophrenia but less severe, and providing psychiatric care to these individuals has been shown to help prevent psychosis.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 16 to 35
You may be able to join if
- meeting Criteria of Psychosis-Risk Syndromes (COPS) criteria on the Structured Interview for Psychosis-Risk Syndromes (SIPS)
- capacity to provide informed consent
- if female, participant is not of child-bearing potential, defined as females who have undergone a sterilization procedure or have been...
You likely can't join if
- meeting criteria for any other DSM-5 diagnosis at the time of the study (except -personality disorder, nicotine use disorder, or other substance use...
- concomitant or past neurological condition
- visual impairment which is not corrected to normal by prescription glasses history of reading disability
- past antipsychotic treatment at a therapeutic dose
- current treatment with a psychotropic medication except antidepressants on which the participants has been on a stable dose for at least 30 days.
- pregnancy (as identified on self-report and/or rapid urine pregnancy test) or intent to become pregnant according to self-report
See the full eligibility criteria
- meeting Criteria of Psychosis-Risk Syndromes (COPS) criteria on the Structured Interview for Psychosis-Risk Syndromes (SIPS)
- capacity to provide informed consent
- if female, participant is not of child-bearing potential, defined as females who have undergone a sterilization procedure or have been post-menopausal for at least 1 year prior to screening OR participant is of...
- meeting criteria for any other DSM-5 diagnosis at the time of the study (except -personality disorder, nicotine use disorder, or other substance use disorder in full remission)
- concomitant or past neurological condition
- visual impairment which is not corrected to normal by prescription glasses history of reading disability
- past antipsychotic treatment at a therapeutic dose
- current treatment with a psychotropic medication except antidepressants on which the participants has been on a stable dose for at least 30 days.
- pregnancy (as identified on self-report and/or rapid urine pregnancy test) or intent to become pregnant according to self-report
- breastfeeding or plan to do so
- history of kidney stones
- current treatment with an antibiotic
- current treatment with nitroglycerin
- allergy to any ingredients in either the investigational product or placebo product
The study team makes the final eligibility decision.
Where it's taking place
- Toronto, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 16 years to 35 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Toronto, Ontario, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.