BridgeMD
New treatment option for HFpEF
Official title Muscle Blood Flow Regulation in HFpEF
ClinicalTrials.gov ID: NCT05115890
What this study is testing
- What it's testing
- Heart failure with preserved ejection (HFpEF) disproportionately affects Veterans and is the number one reason for hospital discharge in the VA Health Care System. Exercise intolerance is a common complication experienced by patients with HFpEF, perpetuating physical inactivity and accelerating disease progression.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- Age 18 years or older and able to give written informed consent
- New York Heart Association (NYHA) functional class II or III
- Left Ventricular Ejection Fraction (LVEF) \> 50%
- Plasma Brain Natriuretic Peptide (BNP) \>200 pg/mL or NT-proBNP 400 pg/mL at enrollment
You likely can't join if
- Prior EF of \<50%.
- NYHA Class IV or HF that cannot be stabilized on optimized pharmacotherapy
- Acute coronary syndrome, infiltrative cardiomyopathy, or myocarditis
- Patients with HFpEF secondary to significant uncorrected primary valvular disease (except mitral regurgitation secondary to left ventricular...
- Orthopedic limitations that would prohibit knee-extensor exercise
- Women currently taking hormone replacement therapy (HRT) will be excluded from the proposed studies due to the direct vascular effects of HRT
See the full eligibility criteria
- Age 18 years or older and able to give written informed consent
- New York Heart Association (NYHA) functional class II or III
- Left Ventricular Ejection Fraction (LVEF) \> 50%
- Plasma Brain Natriuretic Peptide (BNP) \>200 pg/mL or NT-proBNP 400 pg/mL at enrollment
- Prior EF of \<50%.
- NYHA Class IV or HF that cannot be stabilized on optimized pharmacotherapy
- Acute coronary syndrome, infiltrative cardiomyopathy, or myocarditis
- Patients with HFpEF secondary to significant uncorrected primary valvular disease (except mitral regurgitation secondary to left ventricular dysfunction)
- Orthopedic limitations that would prohibit knee-extensor exercise
- Women currently taking hormone replacement therapy (HRT) will be excluded from the proposed studies due to the direct vascular effects of HRT
- Women who are pregnant or may become pregnant, but the typical age of female patients with HFpEF will be postmenopausal
- Current smokers
The study team makes the final eligibility decision.
Where it's taking place
- Salt Lake City, Utah, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Salt Lake City, Utah, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.