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New treatment option for Pancreatic Cancer
Official title Pembrolizumab With Olaparib as Combined Therapy in Metastatic Pancreatic Cancer
ClinicalTrials.gov ID: NCT05093231
What this study is testing
What is Pembrolizumab?
Pembrolizumab is an investigational medicine, being studied as a potential treatment for pancreatic cancer.
Also referred to as Keytruda, MK-3475.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- A phase II study combining pembrolizumab with olaparib in metastatic pancreatic adenocarcinoma patients with high tumour mutation burden
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Aged ≥ 18 years old
- Written informed consent
- Histologically or cytologically confirmed PDA
- Confirmation that the PDA has TMB \>4 mutations/Mb, or dMMR gene mutation, or MSI-H by IHC. TMB status and dMMR can be obtained from either tissue...
- Radiologically confirmed stage 4 mPDA, with measurable disease
You likely can't join if
- Patients with resectable or locally advanced PDA
- Other invasive malignancies diagnosed within the last 2 years which have not been treated with curative intent
- Prior immune checkpoint inhibitors or PARP inhibitors. This includes any prior therapy with an anti-PD-1, or anti-PD-L1, or anti-PD-L2 agent, or with...
- Requirement for non-physiological dose of daily oral steroids, or regular use of any other immunosuppressive agents; prednisolone dose of \< 10mg (or...
- Significant acute or chronic medical or psychiatric condition, disease or laboratory abnormality, which in the judgment of the investigator would...
- A history of chronic obstructive pulmonary disease, interstitial lung disease, sarcoidosis, idiopathic pulmonary fibrosis, pulmonary hypersensitivity...
See the full eligibility criteria
Who can join
- Aged ≥ 18 years old
- Written informed consent
- Histologically or cytologically confirmed PDA
- Confirmation that the PDA has TMB \>4 mutations/Mb, or dMMR gene mutation, or MSI-H by IHC. TMB status and dMMR can be obtained from either tissue, or blood.
- Radiologically confirmed stage 4 mPDA, with measurable disease
- Received no more than 1 prior systemic therapy regimen for unresectable (stage 3 or 4) PDA is allowed
- Measurable disease which has not been irradiated in prior radiotherapy
- Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0 or 1
- Life expectancy \>12 weeks from the date of screening assessment
- Adequate bone marrow function:
- Absolute neutrophil count (ANC) ≥1.5 x 109 /L
- Haemoglobin (Hb) ≥ 90 g/L
- Platelets ≥100 x 109 /L
- Adequate liver function:
- Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) ≤2.5 x upper limit of normal range (ULN), or \<5 x ULN in the presence of liver metastases
- Total bilirubin \<1.5 x ULN
- Adequate renal function defined as a calculated creatinine clearance by Cockcroft - Gault of ≥50 mL/min
What rules you out
- Patients with resectable or locally advanced PDA
- Other invasive malignancies diagnosed within the last 2 years which have not been treated with curative intent
- Prior immune checkpoint inhibitors or PARP inhibitors. This includes any prior therapy with an anti-PD-1, or anti-PD-L1, or anti-PD-L2 agent, or with an agent directed to another stimulatory or co-inhibitory T-cell...
- Requirement for non-physiological dose of daily oral steroids, or regular use of any other immunosuppressive agents; prednisolone dose of \< 10mg (or equivalent steroid dose) is allowed. Use of inhaled or topical...
- Significant acute or chronic medical or psychiatric condition, disease or laboratory abnormality, which in the judgment of the investigator would place the patient at undue risk or interfere with the trial. Examples...
- A history of chronic obstructive pulmonary disease, interstitial lung disease, sarcoidosis, idiopathic pulmonary fibrosis, pulmonary hypersensitivity pneumonitis, cystic fibrosis or bronchiectasis affecting pulmonary...
- Uncontrolled ischaemic heart or other cardiovascular event (myocardial infarction, new angina, stroke transient ischaemic attack, or new congestive cardiac failure) within the last 2 months
- Stable but significant cardiovascular disease defined by heart failure (New York Heart Association Functional Classification III or IV) or frequent angina
- Presence of active infection
- Cirrhotic liver disease, known HIV, chronic active or acute hepatitis B, or hepatitis C
- History of severe allergy or hypersensitivity reactions
- Autoimmune disease requiring chronic use of immunosuppressive agents.
- Replacement therapy using physiological doses for adrenal or pituitary insufficiency is allowed.
- Known additional malignancy that is progressing or has required active treatment within the past 3 years. Note: Participants with basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or carcinoma in...
- Has known brain metastases and/or carcinomatous meningitis
- Has myelodysplastic syndrome (MDS)/acute myeloid leukaemia (AML) or with features suggestive of MDS/AML.
- Women who are pregnant, or plan to become pregnant or are lactating.
- Women of child-bearing potential and male patients who are unwilling to adhere to the contraception requirement from informed consent until the last dose of the trial treatment and for 120 days after the last dose of...
- Patients unable to swallow orally administered medication and patients with gastrointestinal disorders likely to interfere with absorption of the trial medication.
- Concomitant use of known potent CYP3A4 inhibitors and inducers. Restrictions relating to concomitant medications are described in section 10.9. Please consider wash-out periods.
- Has received prior systemic anti-cancer therapy including investigational agents within 4 weeks prior to screening.
- Has severe hypersensitivity (≥Grade 3) to pembrolizumab and/or any of its excipients
- Has received prior radiotherapy within 2 weeks of start of study intervention. Participants must have recovered from all radiation-related toxicities, not require corticosteroids, and not have had radiation pneumonitis...
- Has received a live vaccine or live-attenuated vaccine within 30 days before the first dose of study intervention. Administration of killed vaccines is allowed.
- Participant received colony-stimulating factors (e.g., granulocyte colony-stimulating factor [G-CSF], granulocyte-macrophage colony-stimulating factor [GM CSF] or recombinant erythropoietin) within 28 days prior to the...
- Is currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of study intervention.
- Participant has persistent toxicities (\>CTCAE Grade 2) caused by previous cancer therapy, excluding alopecia.
- Has had an allogenic tissue/solid organ transplant
- Judgment by the Investigator that the patient should not participate in the trial.
The study team makes the final eligibility decision.
Where it's taking place
- Melbourne, Australia
- Richmond, Australia
- Cambridge, Cambridgeshire, United Kingdom
- Bodelwyddan, United Kingdom
- Cardiff, United Kingdom
- Coventry, United Kingdom
- Glasgow, United Kingdom
- Leeds, United Kingdom
- Liverpool, United Kingdom
- London, United Kingdom
- Manchester, United Kingdom
- Milton Keynes, United Kingdom
- Norwich, United Kingdom
- Nottingham, United Kingdom
- Plymouth, United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Melbourne, Australia; Richmond, Australia; Cambridge, Cambridgeshire, United Kingdom; Bodelwyddan, United Kingdom; Cardiff, United Kingdom; Coventry, United Kingdom and 9 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.