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New treatment option for Postoperative Atrial Fibrillation
Official title Post-Operative Atrial Fibrillation After Surgical Aortic Valve Replacement and the Influence of Statins
ClinicalTrials.gov ID: NCT05062239
What this study is testing
What is Discontinuance of treatment with statins 7 to 14 days prior to surgery until 30 days postoperative?
Discontinuance of treatment with statins 7 to 14 days prior to surgery until 30 days postoperative is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for postoperative atrial fibrillation.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Statins have rapid and significant actions that have potentially important (but not yet proven) implications for postoperative atrial fibrillation and cardiac protection in patients undergoing cardiac surgery. The focus of this study is, therefore, on patients having surgical aortic valve replacement (with aortotomy) and the development of postoperative atrial fibrillation (POAF).
- Time commitment: about 3 months
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 60 to 95
You may be able to join if
- Patients undergoing elective solitary SAVR with bioprosthesis
- Patients who are in sinus rhythm and not taking any anti-arrhythmic medication, other than beta-adrenergic blocking agents, at the time of surgery
- In treatment with HMG-CoA reductase inhibitors in the past 3 months and of at least 7 days
- Age \>60 years
- Willingness and provision of informed consent to be assigned by chance
You likely can't join if
- Prior history of atrial fibrillation
- Prior history of cardiac surgery
- Hepatic dysfunction (Alanin-aminotransferase more than twice the upper limit)
- Creatinine \>200 µmol/L
The study team makes the final eligibility decision.
Where it's taking place
- Odense, Denmark
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The study runs about 3 months per participant, based on its public description. The team confirms the exact schedule and number of visits before you enroll.
Who can join this trial?
This study is enrolling all sexes, 60 years to 95 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Odense, Denmark. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.