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New treatment option for Vasoplegia
Official title Midodrine for the Early Liberation of Vasopressor Support in the ICU (LIBERATE Multi-Site)
ClinicalTrials.gov ID: NCT05058612
What this study is testing
What is Midodrine?
Midodrine is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for vasoplegia.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Vasopressors are medications that are given intravenously to increase the blood pressure of patients with illnesses that cause dangerous blood pressure drops. When a doctor prescribes a vasopressor, they ask that the dose be adjusted to achieve a specific blood pressure.
- Phase 4: studies an already-approved treatment
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- Age \> 18 years
- Ongoing vasopressor support
- Decreasing vasopressor dose(s)
You likely can't join if
- Greater than 24 hours from peak vasopressor dose
- Contraindication to enteral medications
- Previously received midodrine in last 7 days
- Expected death or anticipated withdrawal of life-sustaining therapies in next 24 hours
- Pregnancy
- Known allergy to midodrine
The study team makes the final eligibility decision.
Where it's taking place
- Edmonton, Alberta, Canada
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Edmonton, Alberta, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.