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New treatment option for Neuroendocrine Tumor of Pancreas
Official title Precision Radiotherapy Using MR-linac for Pancreatic Neuroendocrine Tumours in MEN1 Patients
ClinicalTrials.gov ID: NCT05037461
What this study is testing
- What it's testing
- Patients with the Multiple Endocrine Neoplasia type 1 (MEN1) syndrome are genetically predisposed for developping multiple pancreatic neuro-endocrine tumours (pNET). The management of small (pNET) in both MEN1 and sporadic cases, pose a major clinical challenge.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- All patients meeting the following criteria will be assessed for in the tumour board:
- lesions measuring between 2cm and 3cm.
- pNET lesions with a size between 1.0 and 2.0 cm and moderate growth of the lesion (2-4 mm/ year) on sequential follow-up scans.
- pNET lesions with a size between 1.0 and 2.0 cm and minimal growth of the lesion (1 mm/ year) reconfirmed on 3 or more sequential follow-up scans.
- Patients with in situ remaining 1.0 - 2.0 cm lesions after previous resection of a larger lesion. All patients with such lesion and an indication for...
You likely can't join if
- Suspected malignant pNET as per the tumour board assessment, including the criteria:
- pNET lesions of more than 3 cm in size
- rapid growth of pNET lesions with more than 4mm per year
- Symptomatic pNET because of hormone production, with the exception of gastrinomas which are located in the submucosa of the duodenum
- concurrent treatment with a somatostatin analog
- concurrent treatment with chemotherapy
See the full eligibility criteria
- All patients meeting the following criteria will be assessed for in the tumour board:
- lesions measuring between 2cm and 3cm.
- pNET lesions with a size between 1.0 and 2.0 cm and moderate growth of the lesion (2-4 mm/ year) on sequential follow-up scans.
- pNET lesions with a size between 1.0 and 2.0 cm and minimal growth of the lesion (1 mm/ year) reconfirmed on 3 or more sequential follow-up scans.
- Patients with in situ remaining 1.0 - 2.0 cm lesions after previous resection of a larger lesion. All patients with such lesion and an indication for surgery are considered eligible for participation in the PRIME study.
- Suspected malignant pNET as per the tumour board assessment, including the criteria:
- pNET lesions of more than 3 cm in size
- rapid growth of pNET lesions with more than 4mm per year
- Symptomatic pNET because of hormone production, with the exception of gastrinomas which are located in the submucosa of the duodenum
- concurrent treatment with a somatostatin analog
- concurrent treatment with chemotherapy
- peptide receptor radionuclide therapy in the past 12 months
- history of radiotherapy in the upper abdominal region
- MRI contraindications as per usual clinical care, such as claustrophobia and metal or electronic implants not compatible with MRI.
- Pregnancy
- (Other) metastatic disease
- WHO performance score 3-4
The study team makes the final eligibility decision.
Where it's taking place
- Utrecht, Netherlands
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Utrecht, Netherlands. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.