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New treatment option for Residual, Progressive or Recurrent Grade II or III Meningioma
Official title NEO100 and High-Grade Meningioma
ClinicalTrials.gov ID: NCT05023018
What this study is testing
What is NEO100?
NEO100 is an investigational medicine, given as an once-daily inhaled treatment, being studied as a potential treatment for residual, progressive or recurrent grade ii or iii meningioma.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This multi-site, Phase 2 clinical trial is an open-label study to identify the safety, pharmacokinetics, and efficacy of a repeated dose regimen of NEO100 (perillyl alcohol) for the treatment of patients with residual high-grade meningioma following resection surgery, radiographically-confirmed progression of high-grade meningioma or recurrent high-grade meningioma. There will be up to 30 patients enrolled in this study to have 29 evaluable patients.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 12 and older
You may be able to join if
- Patient must:
- Have histologically confirmed WHO Grade II or III meningioma that is residual, progressive or recurrent following at least minimally safe resection...
- Residual disease is defined as residual measurable disease (without a requirement for progression). Residual measurable disease is defined by...
- Progressive disease is defined as an increase in size of the measurable primary lesion on imaging by 25% or more (bidirectional area). The change...
- Recurrent disease is defined as new evidence of measurable disease following complete resection (10mm in both dimensions).
You likely can't join if
- Patients who have had chemotherapy, targeted small molecule therapy or study therapy within 14 days (or 5 half-lives, whichever is shorter) of study...
- Patient has completed chemo-radiation within the last 84 days prior to the first administration of study drug, unless new contrast enhancement is...
- Patient has had surgery within seven days prior to the date of informed consent.
- Patient has had cytotoxic chemotherapy within 4 weeks (or 5 half-lives, whichever is shorter), nitrosoureas/alkylating agents within 6 weeks or...
- Prior treatment with interstitial brachytherapy within 6 months of start of study therapy.
- Current or planned participation in a clinical trial of an investigational agent or using an investigational medical device.
See the full eligibility criteria
Who can join
- Patient must:
- Have histologically confirmed WHO Grade II or III meningioma that is residual, progressive or recurrent following at least minimally safe resection and radiation therapy. Metastatic meningiomas are allowed.
- Residual disease is defined as residual measurable disease (without a requirement for progression). Residual measurable disease is defined by bidimensionally measurable lesions with clearly defined margins by MRI...
- Progressive disease is defined as an increase in size of the measurable primary lesion on imaging by 25% or more (bidirectional area). The change must occur between scans separated by no more than 24 months.
- Recurrent disease is defined as new evidence of measurable disease following complete resection (10mm in both dimensions).
- Be on a stable or decreasing dose of steroids for at least five days prior to the date of informed consent.
- Participants must have failed maximal safe resection and radiation therapy.
- There is no limit on the number of prior surgeries, radiation therapy, radiosurgery treatments or systemically administered therapeutic agents, however, these treatment(s) must comply with the following:
- There is no limit on the number of prior therapies.
- Prior medical therapy is allowed but is not required.
- No chemotherapy, other investigational agents within 14 days of study treatment.
- For prior systemic agents, participants must be at least 4 weeks (or 5 half-lives, whichever is shorter) from other prior cytotoxic chemotherapy (6 weeks from nitrosoureas/alkylating agents) or biologic therapies.
- No other concurrent receipt of investigational agents or other meningioma-directed therapy (chemotherapy, radiation) while on study.
- Patients may have been treated with standard external beam radiation or radiosurgery in any combination; however an interval of ≥12 weeks (84 days) must have elapsed from the completion of the radiation therapy to the...
- An interval of ≥ 28 days and full recovery (no ongoing safety issues) from surgical resection is required;
- Meningiomas that have resulted from prior radiation therapy are allowed.
- There must be an interval of ≥ 7 days from stereotactic biopsy; and
- Participants must have recovered to grade ≤1 or pretreatment baseline from clinically significant adverse events related to prior therapy (exclusions include, but are not limited to alopecia, laboratory values listed...
- Patient must be ≥ 12 years of age.
- Patient must have an ECOG performance status of 0-2 or KPS ≥ 60.
- Patient must have an expected survival of at least three months.
- Patient must be willing to provide blood sample for pharmacokinetic study (to assess proper administration of NEO100).
- Patient must have adequate organ and marrow function as defined below:
- White blood cell (WBC) ≥2000/microliter
- Absolute neutrophil count (ANC) ≥ 1,500/microliter
- Platelets ≥ 100,000/microliter
- Hemoglobin ≥9 gm/dl
- AST (SGOT)/ALT (SPGT) ≤ 2.5 × laboratory upper limit of normal (ULN)
- Serum creatinine ≤ 1.5 x laboratory upper limit of normal (ULN) or
- Creatinine clearance (meas or calc) ≥60mL/min for participants with creatinine levels \>1.5x laboratory upper limit of normal (ULN)
- Total serum bilirubin ≤ 1.5 x laboratory upper limit of normal (ULN) except participants with Gilbert's Syndrome who can have a total serum bilirubin of \<5 x laboratory upper limit of normal (ULN)
- MRI (or CT if MRI contraindicated) within 14 days prior to start of study drug. Corticosteroid dose must be stable or decreasing for at least 5 days prior to the scan. If steroids are added or the steroid dose is...
- Female patients of child-bearing potential and male patients must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) for 30 days prior to the first administration of study...
- A female of child-bearing potential is any woman (regardless of sexual orientation, not having undergone a tubal ligation, or remaining celibate by choice) who meets the following criteria:
- Has not undergone a hysterectomy or bilateral oophorectomy; or
- Has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months).
- A negative serum pregnancy test will be required of all female patients of child-bearing potential within seven days prior to initiating study drug.
- A serum pregnancy test will be repeated immediately if pregnancy is suspected.
- Women must not be breastfeeding.
- Patient must have the ability to understand, and the willingness comply with scheduled visits, treatment schedule, laboratory testing and other requirements of the study as confirmed by signing a written informed...
What rules you out
- Patients who have had chemotherapy, targeted small molecule therapy or study therapy within 14 days (or 5 half-lives, whichever is shorter) of study treatment.
- Patient has completed chemo-radiation within the last 84 days prior to the first administration of study drug, unless new contrast enhancement is outside of radiation field, or there is tissue proven recurrence or...
- Patient has had surgery within seven days prior to the date of informed consent.
- Patient has had cytotoxic chemotherapy within 4 weeks (or 5 half-lives, whichever is shorter), nitrosoureas/alkylating agents within 6 weeks or biologic therapies.
- Prior treatment with interstitial brachytherapy within 6 months of start of study therapy.
- Current or planned participation in a clinical trial of an investigational agent or using an investigational medical device.
- The patient's disease is primarily localized to the brainstem or spinal cord;
- Patient has not recovered from adverse events due to chemotherapy, immunotherapy, or radiation therapy.
- Patient has had prior treatment with perillyl alcohol.
- Patient has a history of allergic reactions attributed to perillyl alcohol.
- Patient has uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social...
- Patient must not be pregnant or nursing due to the potential for congenital abnormalities and the potential of this regimen to harm nursing infants.
- Patient has a history of new diagnosis or treatment of cancer other than high-grade meningioma within five years prior to the date of informed consent, except for basal cell carcinoma or squamous cell carcinoma of the...
- Leptomeningeal involvement of the patient's tumor.
The study team makes the final eligibility decision.
Where it's taking place
- Los Angeles, California, United States
- San Francisco, California, United States
- Santa Monica, California, United States
- Boston, Massachusetts, United States
- Dallas, Texas, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 12 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Los Angeles, California, United States; San Francisco, California, United States; Santa Monica, California, United States; Boston, Massachusetts, United States; Dallas, Texas, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.