BridgeMD
New treatment option for Critical Illness
Official title Preventing Cardiovascular Collapse With Vasopressors During Tracheal Intubation
ClinicalTrials.gov ID: NCT05014581
What this study is testing
What is Noradrenaline?
Noradrenaline is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for critical illness.
Also referred to as Norepinephrine.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Tracheal intubation (TI) is associated with a high risk of adverse events in critically ill patients and peri-intubation hemodynamic collapse is the most commonly observed. The primary aim of the PREVENTION trial is to compare the effect of the pre-emptive use of noradrenaline versus no peri-intubation use of noradrenaline on incidence of cardiovascular collapse following TI in adult critically ill patients.
- Phase 3: a large, late-stage study
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 90
You may be able to join if
- Patient is admitted or scheduled for admission to a participating study hospital
- Planned procedure is tracheal intubation and planned operator is a provider expected to routinely perform endotracheal intubation in the...
- Critical illness (i.e. life-threatening condition with intubation required for cardiorespiratory failure or neurological impairment)
- Administration of sedation (with or without neuromuscular blockade) is planned
- Age 18 years or older
You likely can't join if
- No vasopressors/inotropes at the moment of screening for eligibility
- MAP \ 120 mmHg at the moment of screening for eligibility
- Urgency of intubation precludes safe performance of study procedures
- Intubation performed during cardiopulmonary resuscitation of a patient in cardiac arrest
- Enrolled in another clinical trial that is unapproved for co-enrollment
- Pregnant or suspected pregnancy
The study team makes the final eligibility decision.
Where it's taking place
- Nantes, France
- Galway, Ireland
- Rozzano, Milan, Italy
- Orbassano, Turin, Italy
- Milan, Italy
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 90 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Nantes, France; Galway, Ireland; Rozzano, Milan, Italy; Orbassano, Turin, Italy; Milan, Italy. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.