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New treatment option for Anterior Cruciate Ligament Reconstruction
Official title Immunometabolic Mechanisms of Blood Flow Restriction (BFR) Training After Anterior Cruciate Ligament Reconstruction
ClinicalTrials.gov ID: NCT05012982
What this study is testing
- What it's testing
- This is a crossover phase 4 study to evaluate the impact of blood flow restriction on immunometabolism and gene expression in immune cells in individuals undergoing rehabilitation from anterior cruciate ligament reconstruction.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 60. Healthy volunteers may be eligible.
You may be able to join if
- Provision of signed and dated informed consent form
- Stated willingness to comply with all study procedures and availability for two study visits at least 1 week apart
- All genders, between 18 and 60 years of age
- In good general health without any underlying medical conditions or prior injury that would place the subject at risk of further injury/illness by...
You likely can't join if
- Serious medical conditions including cardiovascular, metabolic (diabetes), rheumatologic, pulmonary, or musculoskeletal.
- Multiple ligament ruptures or trauma
- Rheumatoid arthritis or other significant comorbidities
- Lower extremity vascular pathology, including history of deep vein thrombosis
- Those with a history of sickle cell trait or disease
- Use of anticoagulant medications
See the full eligibility criteria
- Provision of signed and dated informed consent form
- Stated willingness to comply with all study procedures and availability for two study visits at least 1 week apart
- All genders, between 18 and 60 years of age
- In good general health without any underlying medical conditions or prior injury that would place the subject at risk of further injury/illness by participating in the study
- Serious medical conditions including cardiovascular, metabolic (diabetes), rheumatologic, pulmonary, or musculoskeletal.
- Multiple ligament ruptures or trauma
- Rheumatoid arthritis or other significant comorbidities
- Lower extremity vascular pathology, including history of deep vein thrombosis
- Those with a history of sickle cell trait or disease
- Use of anticoagulant medications
- Pregnancy
- Treatment with another investigational drug or other intervention within one month of Study Day 1
- Current smoker or tobacco use within 3 months of Study Day 1
- Febrile illness within 2 weeks of Study Day 1
The study team makes the final eligibility decision.
Where it's taking place
- Milford, Connecticut, United States
- North Haven, Connecticut, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 60 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Milford, Connecticut, United States; North Haven, Connecticut, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.