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Official title Inspiratory Muscle Strength Training for Lowering Blood Pressure and Improving Endothelial Function in Postmenopausal Women: Comparison With "Standard of Care" Aerobic Exercise
ClinicalTrials.gov ID: NCT05000515
What this study is testing
- What it's testing
- High blood pressure (BP) is the major modifiable risk factor for cardiovascular diseases (CVD) and related health conditions, particularly among postmenopausal (PM) women. In adults age ≥50 years this risk is primarily driven by above-normal systolic BP (SBP ≥120 mmHg), as diastolic BP plateaus, then decreases in older adulthood.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 50 and older, women only. Healthy volunteers may be eligible.
You may be able to join if
- Postmenopausal women (\>12 months of amenorrhea)
- Estrogen deficient (no hormone therapies within the previous 12 months)
- Age 50 years and older
- Ability to provide informed consent
- Willing to accept random assignment to condition
You likely can't join if
- Younger than age 50 years
- Early menopause (menopause before age 45 years)
- Having had a hysterectomy
- History of uncontrolled hypertension (systolic blood pressure \>180 mmHg and/or diastolic blood pressure \>120 mmHg)
- Current smoker
- Alcohol dependence or abuse
See the full eligibility criteria
- Postmenopausal women (\>12 months of amenorrhea)
- Estrogen deficient (no hormone therapies within the previous 12 months)
- Age 50 years and older
- Ability to provide informed consent
- Willing to accept random assignment to condition
- Resting systolic blood pressure of 120 mmHg or greater
- Body mass index \<40 kg/m2
- Weight stable in the prior 3 months (\<2 kg weight change) and willing to remain weight stable throughout study
- No change in blood pressure medications or other medications (prescription or dosing) in the prior 3 months and willing to maintain current medication regimen
- Free from clinical disease with the exception of hypertension
- Younger than age 50 years
- Early menopause (menopause before age 45 years)
- Having had a hysterectomy
- History of uncontrolled hypertension (systolic blood pressure \>180 mmHg and/or diastolic blood pressure \>120 mmHg)
- Current smoker
- Alcohol dependence or abuse
- Abnormal blood pressure response to exercise (drop in systolic blood pressure below resting levels or systolic blood pressure \>260 mmHg or diastolic blood pressure \>115 mmHg)
- Regular vigorous aerobic/endurance exercise (\>4 bouts/week, \>30 min/bout at a workload \>6 METS)
The study team makes the final eligibility decision.
Where it's taking place
- Boulder, Colorado, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 50 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Boulder, Colorado, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.