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New treatment option for Blood Pressure
Official title Mitigating the Pro-inflammatory Phenotype of Obesity
ClinicalTrials.gov ID: NCT04934228
What this study is testing
What is Hydrochlorothiazide 12.5Mg Tab?
Hydrochlorothiazide 12.5Mg Tab is an investigational medicine, given as a twice-daily pill taken by mouth, being studied as a potential treatment for blood pressure.
Also referred to as Hydrochlorothiazide.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this study is to examine the hypothesize that 4 weeks of sympathetic nerve activity (SNA) inhibition (oral clonidine) will cause a significant reduction in circulating blood concentrations and endothelial cell expression of inflammatory markers (e.g., TNF-α, IL-6). Our study is a prospective study using a randomized, double-blinded design to test 4 weeks of SNA blockade (oral clonidine) compared with a BP-lowering control condition (diuretic, hydrochlorothiazide) or a placebo.
- Phase 1: an early, usually small safety study
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 79
You may be able to join if
- Male or Female, age 18-79
- Obese: BMI \> 30 m/kg2
- Hypertensive: blood pressure \>130/80
- Elevated insulin resistance (HOMA-IR \> 2.5)
- Waist circ: \>102 cm (men) and \>88 cm (women)
You likely can't join if
- Current use of clonidine or beta-blockers
- Current smoker or History of smoking in the past 3 months.
- Hyperlipidemia: Fasting triglycerides \> 250 mg/dL
- Currently taking hypertension medication
- History of heart disease (e.g., myocardial infarction, stent, byass, heart attack, stroke, heart failure, valvular heart disease, cardiomyopathy)
- History of neurological disorders
See the full eligibility criteria
- Male or Female, age 18-79
- Obese: BMI \> 30 m/kg2
- Hypertensive: blood pressure \>130/80
- Elevated insulin resistance (HOMA-IR \> 2.5)
- Waist circ: \>102 cm (men) and \>88 cm (women)
- Fasting glucose \< 126 mg/dL
- Fasting triglycerides \< 250 mg/dL
- HbA1c \< 6.5%
- Willing to visit research lab (Fairway CTSU)
- Willing to undergo a blood draw
- Able to provide written informed consent
- Current use of clonidine or beta-blockers
- Current smoker or History of smoking in the past 3 months.
- Hyperlipidemia: Fasting triglycerides \> 250 mg/dL
- Currently taking hypertension medication
- History of heart disease (e.g., myocardial infarction, stent, byass, heart attack, stroke, heart failure, valvular heart disease, cardiomyopathy)
- History of neurological disorders
- History of transplant
- Actively participating in other studies, except for a registry study.
The study team makes the final eligibility decision.
Where it's taking place
- Kansas City, Kansas, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 79 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Kansas City, Kansas, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.