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Compares treatment options for Skin Pigmentation
Official title Prospective Evaluation of Topical Almond Oil vs Hydroquinone
ClinicalTrials.gov ID: NCT04875715
What this study is testing
What is Hydroquinone Topical?
Hydroquinone Topical is an investigational medicine, given as a treatment applied to the skin, being studied as a potential treatment for skin pigmentation.
Also referred to as Hydroquinone.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this study is to analyze facial pigmentation and skin microbiome changes after topical almond oil application, compared to the use of topical hydroquinone.
- Phase 4: studies an already-approved treatment
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older, women only
You may be able to join if
- Premenopausal women of Fitzpatrick skin types 3 to 6
You likely can't join if
- Those with a nut allergy
- Smoking is an independent risk factor and serves as a confounder for the development of facial aging [18]. Therefore current smokers, those that have...
- Those with an autoimmune photosensitive condition or a known genetic condition with a deficiency in collagen production (such as Ehlers-Danlos...
- Hormonal medications or therapies will not be allowed unless they have been stable on their medications for at least 2 months. Examples include oral...
- Those who have undergone any cosmetic procedures to the face in the 4 months prior to enrollment in the opinion of the investigator. People that have...
- Individuals who are unwilling to discontinue vitamin E containing supplements and food sources during the washout and intervention.
See the full eligibility criteria
- Premenopausal women of Fitzpatrick skin types 3 to 6
- Those with a nut allergy
- Smoking is an independent risk factor and serves as a confounder for the development of facial aging [18]. Therefore current smokers, those that have smoked within the past year, and former smokers with greater than a...
- Those with an autoimmune photosensitive condition or a known genetic condition with a deficiency in collagen production (such as Ehlers-Danlos syndrome) will be excluded as this can be a confounder for facial photoaging.
- Hormonal medications or therapies will not be allowed unless they have been stable on their medications for at least 2 months. Examples include oral contraceptives, progesterone-based injections, and estrogen based...
- Those who have undergone any cosmetic procedures to the face in the 4 months prior to enrollment in the opinion of the investigator. People that have undergone deeper chemical peels (TCA based peels) within 1 year prior...
- Individuals who are unwilling to discontinue vitamin E containing supplements and food sources during the washout and intervention.
- Individual who are unwilling to discontinue topical cosmetic products during the duration of the study.
- Individuals who are not willing to engage in a two-week washout on topical treatments known to affect facial pigmentation and these agents will be restricted during the study period as well. These include topicals that...
- Retinoids such as tretinoin, adapalene, retinol.
- Antioxidant ingredients such as vitamin C or vitamin E.
- Pigment-reducing agents such as hydroquinone, azelaic acid, kojic acid per the discretion of the investigator except for the hydroquinone that is provided in this study.
- Topicals that contain a nut oil or nut extract as part of their ingredient list.
- Furthermore, people will be asked to refrain from use of any other topical products for one week prior to each visit apart from the study agents supplied from this study.
The study team makes the final eligibility decision.
Where it's taking place
- Sacramento, California, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Sacramento, California, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.