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New treatment option for Myelodysplastic Syndrome
Official title Revisiting the Universal Donor: Does Exposure to O Blood Products Affect Patient Outcomes?
ClinicalTrials.gov ID: NCT04859218
What this study is testing
- What it's testing
- In a recent analysis of a large transfusion database (Transfusion Research Utilization, Surveillance and Tracking database [TRUST]), the investigators found that the transfusion of ABO non-identical RBCs to group A individual was associated with an increased risk of death in-hospital compared to patients transfused with ABO identical RBCs (Red Blood Cells). Our finding was corroborated in a separate study of low birth weight neonates who received only group O RBCs (e.g., group O neonates received ABO identical RBCs but group A, B, and AB neonates received ABO non-identical RBCs).
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 120
You may be able to join if
- Age ≥ 18 years of age
- Diagnosis of MDS (Myelodysplastic syndrome ) without leukemia (IPSS-R classified or physician indicated either low-risk or intermediate-1)
- Stable disease (as assessed by the patient's physician using MDS Stability Assessment Algorithm)
- Blood group A, B, or AB
- Requiring 2 RBC units at least every 6 weeks or less
You likely can't join if
- Unable to provide informed consent
- Blood group O
- Clinical requirement for special products because of reactions (e.g. washed or volume-reduced)
See the full eligibility criteria
- Age ≥ 18 years of age
- Diagnosis of MDS (Myelodysplastic syndrome ) without leukemia (IPSS-R classified or physician indicated either low-risk or intermediate-1)
- Stable disease (as assessed by the patient's physician using MDS Stability Assessment Algorithm)
- Blood group A, B, or AB
- Requiring 2 RBC units at least every 6 weeks or less
- Receiving transfusions in an outpatient setting
- Unable to provide informed consent
- Blood group O
- Clinical requirement for special products because of reactions (e.g. washed or volume-reduced)
The study team makes the final eligibility decision.
Where it's taking place
- Hamilton, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 120 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Hamilton, Ontario, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.