Recruiting PHASE2 Diffuse Large B-cell Lymphoma

Tests treatment safety and results for Diffuse Large B-cell Lymphoma

Official title Efficacy and Safety of MB-CART2019.1 vs. SoC in Lymphoma Patients

ClinicalTrials.gov ID: NCT04844866

What this study is testing

What is MB-CART2019.1?

MB-CART2019.1 is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for diffuse large b-cell lymphoma.

Also referred to as Zamtocabtagene Autoleucel, Zamto-cel.

Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.

What it's testing
In the current protocol version, there are two parts. Part I is a pivotal Phase II randomised, multi-centre, open-label study to evaluate the efficacy and safety of MB-CART2019.1 compared to standard of care therapy in participants with relapsed/refractory diffuse large B-cell lymphoma, who are not eligible for high-dose chemotherapy and autologous stem cell transplantation.
  • Phase 2: a mid-size study of how well it works
  • Which group you join is decided by chance.

A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.

Who can take part

Ages 18 to 70

You may be able to join if

  • Part I:
  • Histologically proven DLBCL and associated subtypes, according to the World Health Organization (WHO) 2016 classification including:
  • DLBCL not otherwise specified (NOS).
  • High-grade B-cell lymphoma (HGBL) with MYC and BCL2 and/or BCL6 rearrangements with DLBCL/blastoid/intermediate histology or HGBL with MYC and BCL2...
  • High-grade BCL, NOS.
See the full eligibility criteria
Who can join
  • Part I:
  • Histologically proven DLBCL and associated subtypes, according to the World Health Organization (WHO) 2016 classification including:
  • DLBCL not otherwise specified (NOS).
  • High-grade B-cell lymphoma (HGBL) with MYC and BCL2 and/or BCL6 rearrangements with DLBCL/blastoid/intermediate histology or HGBL with MYC and BCL2 and/or BCL6 rearrangements (double hit lymphoma/triple hit lymphoma).
  • High-grade BCL, NOS.
  • Primary (thymic) large mediastinal BCL.
  • Disease transformed from an earlier diagnosis of low-grade lymphoma (e.g. an indolent pathology such as follicular lymphoma, marginal zone lymphoma) into DLBCL with DLBCL disease progression subsequent to DLBCL-directed...
  • Follicular lymphoma Grade 3B.
  • Relapsed or refractory disease after first-line chemoimmunotherapy:
  • Refractory disease defined as no CR to first-line therapy (e.g. R-CHOP [rituximab, cyclophosphamide, daunorubicin, vincristine and prednisone]).
  • Progressive disease (PD) after at least 2 full cycles of first-line therapy.
  • Stable disease (SD) after 4 cycles of first-line therapy.
  • PR as best response after at least 6 cycles of first-line therapy and biopsy-proven persistent disease (except where prohibited due to comorbidities) within ≤ 24 months from the start of the first-line therapy.
  • Relapsed disease defined as complete remission to first-line therapy followed by biopsy-proven disease progression (except where prohibited due to comorbidities) within ≤ 24 months from the start of the first-line...
  • Participants must have received adequate first-line therapy containing at least the combination of an anthracycline-based regimen and rituximab (anti-CD20 monoclonal antibody). Local therapies (e.g. radiotherapies) will...
  • Archival paraffin-embedded tumour tissue acquired ≤ 2 years (preferred: ≤ 2 months) prior to screening for the central pathology review to confirm DLBCL diagnosis must be made available for participation in this study...
  • Participants deemed ineligible to receive HDC followed by ASCT based on the treating physician's assessment and meeting the following criteria: EITHER
  • Age ≥ 18 years and
  • Prior ASCT (as first-line consolidation) or
  • Haematopoietic cell transplantation-specific comorbidity index (HCT-CI) \> 3. OR
  • Age ≥ 65 years and ≥ 1of the criteria below:
  • Impaired cardiac function (left ventricular ejection fraction [LVEF] \< 50%), or
  • Impaired renal function (estimated glomerular filtration rate [eGFR] \< 60 mL/min) calculated according to the modified Modification of Diet in Renal Disease (MDRD) formula, or
  • Impaired pulmonary function (diffusing capacity for carbon monoxide or forced expiratory volume in 1 second \< 80%) or dyspnoea on slight activity, or
  • Eastern Cooperative Oncology Group (ECOG) performance status \> 1. OR
  • Age ≥ 70 years. Documentation of the reason for ineligibility for ASCT must be present in the participant's source data. In addition, all participants must fulfil the following criteria:
  • Age ≥ 18 years.
  • Measurable disease according to Lugano criteria. The lesion must be measurable (nodes \> 1.5 cm in the long axis; extranodal lesions \> 1 cm in the long axis) and positive on a positron emission tomography scan.
  • Estimated life expectancy of \> 3 months for other reasons than the primary disease.
  • Women of childbearing potential (WOCBP) must agree to use highly effective contraceptive measures (Pearl index \< 1) or practice true sexual abstinence from any heterosexual intercourse (True abstinence is only...
  • In the opinion of the investigator, the participant must be able to comply with all study-related procedures, medication use and evaluations.
  • Mental capacity and legal ability to consent to participation in the clinical study. Criteria for Exclusion:
  • Contraindications for R-GemOx, BR plus polatuzumab vedotin, cyclophosphamide and fludarabine as judged by the treating physician.
  • Prior chimeric antigen receptor therapy or other genetically modified T-cell therapy.
  • Participants who have received more than one line of treatment for DLBCL or associated subtypes.
  • Prior haematopoietic stem cell transplantation (HSCT; as first-line consolidation) \< 3 months at the time of leukapheresis.
  • ECOG performance status \> 2.
  • Absolute neutrophil count \< 1,000/μL (unless secondary to bone marrow involvement by DLBCL as demonstrated by bone marrow biopsy).
  • Platelet count \< 50,000/μL (unless secondary to bone marrow involvement by DLBCL as demonstrated by bone marrow biopsy).
  • Absolute lymphocyte count \< 100/μL.
  • Participants who have central nervous system (CNS) lymphoma involvement in present or past medical history.
  • Participants with the requirement for urgent therapy due to tumour mass effects.
  • Infection with human immunodeficiency virus.
  • Presence of active or prior hepatitis B or C as indicated by serology (for detailed criteria see Section 10.2.7.10). Treated infection with hepatitis B or C virus unless confirmed to be polymerase chain reaction...
  • Active infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
  • Active, severe systemic fungal, viral or bacterial infection.
  • Known history or evidence of severely immunocompromised state, i.e. corticosteroid treatment \> 10 mg/day for more than 6 months.
  • Has received vaccination with live virus vaccines 6 weeks prior to randomisation.
  • Prior CD19-targeted therapy.
  • Known history or presence of seizure activities or on active anti-seizure medications within the previous 12 months.
  • History or presence of non-malignant CNS disease that, in the judgement of the investigator, may impair the ability to evaluate neurotoxicity.
  • Known history or presence of autoimmune CNS disease, such as multiple sclerosis, optic neuritis or other immunologic or inflammatory disease.
  • Known history or presence of cerebral vascular accident (CVA) within 12 months prior to randomisation. Note: In case of history of CVA \> 12 months prior to leukapheresis, then the participant must not have any unstable...
  • Participants with Richter's transformation or Richter's syndrome.
  • Participants who are concurrently on any other experimental treatments or during the previous 4 weeks or 5 half-lives.
  • Clinical heart failure with New York Heart Association class ≥ 2 or LVEF \< 30% or severe cardiac arrhythmias or QT prolongation (resting QTcF ≥ 450 msec [male] or ≥ 460 msec [female] at screening) that would (according...
  • Resting peripheral oxygen saturation \< 90% on room air.
  • Liver dysfunction as indicated by total bilirubin \> 2.5 × institutional upper limit of normal (ULN), aspartate aminotransferase and/or alanine aminotransferase \> 5 × ULN or typical symptoms like jaundice.
  • Serum creatinine ≥ 2.0 × ULN or eGFR \< 30 mL/min calculated according to the modified MDRD formula.
  • Pregnant or breast-feeding women.
  • Prior history of malignancies other than DLBCL. Exceptions include participants who have been free of the disease for ≥ 3 years prior to screening and participants with adequately treated and removed basal cell...
  • History of severe immediate hypersensitivity to any investigational medicinal product (IMP), auxiliary medicinal product (AxMP), premedication or rescue medication or its excipients that is scheduled to be given during...
  • Major surgery less than 30 days before start of treatment.
  • Any medical condition likely to interfere with assessment of safety or how well it works of study treatment. Part II:
  • Histologically proven DLBCL and associated subtypes, according to the WHO 2016 classification including:
  • DLBCL, NOS.
  • HGBL with MYC and BCL2 and/or BCL6 rearrangements with DLBCL/blastoid/intermediate histology or HGBL with MYC and BCL2 and/or BCL6 rearrangements (double hit lymphoma/triple hit lymphoma).
  • High-grade BCL, NOS.
  • Primary (thymic) large mediastinal BCL.
  • Disease transformed from an earlier diagnosis of low-grade lymphoma (e.g., an indolent pathology such as follicular lymphoma, marginal zone lymphoma) into DLBCL with DLBCL disease progression subsequent to...
  • Follicular lymphoma Grade 3B.
  • Relapsed or refractory disease after first-line chemoimmunotherapy:
  • Refractory disease defined as no CR to first-line therapy (e.g., R-CHOP).
  • PD after at least 2 full cycles of first-line therapy.
  • SD after 4 cycles of first-line therapy.
  • PR as best response after at least 6 cycles of first-line therapy and biopsy-proven persistent disease (except where prohibited due to comorbidities) within ≤ 12 months after completion of first-line treatment.
  • Relapsed disease defined as complete remission to first-line therapy followed by biopsy-proven disease progression (except where prohibited due to comorbidities) within ≤ 12 months after completion of first-line...
  • Participant must have received adequate first-line therapy containing at least the combination of an anthracycline-based regimen and rituximab (anti-CD20 monoclonal antibody). Local therapies (e.g., radiotherapies) will...
  • Archival paraffin-embedded tumour tissue acquired ≤ 2 years (preferred: ≤ 2 months) prior to screening for the central pathology review to confirm DLBCL diagnosis must be made available for participation in this study...
  • Measurable disease according to Lugano criteria. The lesion must be measurable (nodes \> 1.5 cm in the long axis; extranodal lesions \> 1 cm in the long axis) and positive on a positron emission tomography scan.
  • Approved treatment options not suitable according to investigator's assessment. In addition, all participants must fulfil the following criteria:
  • Age ≥ 18 and ≤ 70 years.
  • Estimated life expectancy of \> 3 months for other reasons than the primary disease.
  • ECOG 0-1.
  • Adequate bone marrow function, defined as:
  • Absolute neutrophil count ≥ 1,000/μL (unless secondary to bone marrow involvement by DLBCL as demonstrated by bone marrow biopsy).
  • Platelet count ≥ 50,000/μL (unless secondary to bone marrow involvement by DLBCL as demonstrated by bone marrow biopsy).
  • Absolute lymphocyte count ≥ 100/μL.
  • Adequate organ function, defined as:
  • New York Heart Association class \< 2 or LVEF ≥ 50%.
  • No severe cardiac arrhythmias or QT prolongation (resting QTcF \< 450 msec [male] or \< 460 msec [female] at screening).
  • No clinically relevant pleural effusion or pericardial effusion.
  • Resting peripheral oxygen saturation ≥ 92% on room air.
  • Total bilirubin ≤ 2.0 × ULN, AST and/or ALT ≤ 5 × ULN
  • Serum creatinine \< 1.0 × ULN or eGFR (according to modified MDRD formula) ≥ 60 mL/min.
  • WOCBP must agree to use highly effective contraceptive measures (Pearl index \< 1) or practice true sexual abstinence from any heterosexual intercourse (True abstinence is only acceptable if it is in line with the...
  • In the opinion of the investigator, the participant must be able to comply with all study-related procedures, medication use and evaluations.
  • Mental capacity and legal ability to consent to participation in the clinical study. Criteria for Exclusion:
  • Contraindications for cyclophosphamide and fludarabine as judged by the treating physician.
  • Prior chimeric antigen receptor therapy or other genetically modified T-cell therapy.
  • Participants who have received more than one line of prior therapy for DLBCL or associated subtypes.
  • Prior HSCT (as first-line consolidation) \< 3 months at the time of leukapheresis.
  • Participants who have CNS lymphoma involvement in present or past medical history.
  • Participants with the requirement for urgent therapy due to tumour mass effects.
  • Infection with human immunodeficiency virus.
  • Presence of active or prior hepatitis B or C as indicated by serology. Treated infection with hepatitis B or C virus unless confirmed to be polymerase chain reaction negative.
  • Infection with Treponema pallidum (pathogen causing syphilis).
  • Infection with human T-lymphotropic virus 1.
  • Active infection with SARS-CoV-2.
  • Active, severe systemic fungal, viral, or bacterial infection.
  • Known history or evidence of severely immunocompromised state, i.e. corticosteroid treatment \> 10 mg/day for more than 6 months.
  • Has received vaccination with live virus vaccines within 6 weeks prior to randomisation.
  • Prior CD19-targeted therapy.
  • Known history or presence of seizure activities or on active anti-seizure medications within the previous 12 months.
  • History or presence of non-malignant CNS disease that, in the judgement of the investigator, may impair the ability to evaluate neurotoxicity.
  • Known history or presence of autoimmune CNS disease, such as multiple sclerosis, optic neuritis or other immunologic or inflammatory disease.
  • Known history or presence of CVA within 12 months prior to randomisation. Note: In case of history of CVA \> 12 months prior to leukapheresis, then the participant must not have any unstable or life-threatening...
  • Participants with Richter's transformation or Richter's syndrome.
  • Participants who are concurrently on any other experimental treatments or during the previous 4 weeks or 5 half-lives.
  • Pregnant or breastfeeding woman.
  • Prior history of malignancies other than DLBCL. Exceptions include participants who have been free of the disease for ≥ 3 years prior to screening and participants with adequately treated and removed basal cell...
  • History of severe immediate hypersensitivity to any IMP, AxMP, premedication or rescue medication or its excipients that is scheduled to be given during study participation.
  • Major surgery less than 30 days before start of treatment.
  • Any medical condition likely to interfere with assessment of safety or how well it works of study treatment.

The study team makes the final eligibility decision.

Where it's taking place

  • Graz, Austria
  • Innsbruck, Austria
  • Linz, Austria
  • Vienna, Austria
  • Anderlecht, Belgium
  • Leuven, Belgium
  • Zagreb, Croatia
  • Hradec Králové, Czechia
  • Ostrava, Czechia
  • Helsinki, Finland
  • Oulu, Finland
  • Turku, Finland
  • Créteil, France
  • Lille, France
  • Lyon, France
  • Marseille, France
  • Nantes, France
  • Pessac, France
  • Poitiers, France
  • Toulouse, France

+ 29 more site(s).

Questions & answers

Do participants get paid in this trial?

This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.

Is it free to join, and do I need insurance?

Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.

How long does this study last?

The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.

Who can join this trial?

This study is enrolling all sexes, 18 years to 70 years. The study team makes the final eligibility decision.

Where is this trial taking place?

Study sites include Graz, Austria; Innsbruck, Austria; Linz, Austria; Vienna, Austria; Anderlecht, Belgium; Leuven, Belgium and 43 more location(s). Enter your location above to see the nearest site and check your eligibility.

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BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.