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New treatment option for Multiple Sclerosis
Official title MS-NEUROPLAST: Neuroplasticity of Cortical Areas Induced by Cognitive Training in Patients with Multiple Sclerosis
ClinicalTrials.gov ID: NCT04806568
What this study is testing
- What it's testing
- This clinical study aims to identify MS related beneficial plasticity and by contrast maladaptive reorganization in combination with elements of daily functional status as a response to a cognitive training program
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65. Healthy volunteers may be eligible.
You may be able to join if
- for people with MS:
- Male/female patients aged 18 to 65 years at screening
- Diagnosis of MS according to the 2017 Revised McDonald criteria
- Disability status at screening with an EDSS score of 0 to 6.5
- Relapsing MS and progressive MS as defined by Lublin
You likely can't join if
- for people with MS:
- Patients suspected of not being able or willing to cooperate or comply with study protocol requirements
- Patients meeting criteria for other demyelinating diseases of the CNS
- Patients with active chronic disease (or stable but treated with immune therapy) of the immune system other than MS
- Patients with any other significant CNS disease or serious psychiatric disorder which can interfere with the patient's ability to cooperate or comply...
- Patients unable or unwilling to undergo MRI scans and EEG Inclusion Criteria for Healthy Controls:
See the full eligibility criteria
- for people with MS:
- Male/female patients aged 18 to 65 years at screening
- Diagnosis of MS according to the 2017 Revised McDonald criteria
- Disability status at screening with an EDSS score of 0 to 6.5
- Relapsing MS and progressive MS as defined by Lublin
- Neurologically stable within 1 month prior to screening
- Patients receiving the same Disease Modifying Treatment (DMT) for at least 6 months
- for people with MS:
- Patients suspected of not being able or willing to cooperate or comply with study protocol requirements
- Patients meeting criteria for other demyelinating diseases of the CNS
- Patients with active chronic disease (or stable but treated with immune therapy) of the immune system other than MS
- Patients with any other significant CNS disease or serious psychiatric disorder which can interfere with the patient's ability to cooperate or comply with the study procedure
- Patients unable or unwilling to undergo MRI scans and EEG Inclusion Criteria for Healthy Controls:
- Normal hearing and normal or corrected-to-normal vision Exclusion Criteria for Healthy Controls:
- Any diagnosed neurological, mental, developmental, or psychiatric disorder
- Unrecovered neurological disorders (i.e., stroke, traumatic brain injury)
- Unstable medication within the last 3 months
- Intake of central nervous drugs (e.g., antidepressants)
- Severe physical disorder
- Concurrent participation in another relevant study
- Patients unable or unwilling to undergo EEG measurements
The study team makes the final eligibility decision.
Where it's taking place
- Thessaloniki, Central Macedonia, Greece
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Thessaloniki, Central Macedonia, Greece. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.