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New treatment option for Mild Cognitive Impairment
Official title Evaluate the Effect of Atorvastatin on Cerebrovascular Reactivity in Mild Cognitive Impairment (MCI)
ClinicalTrials.gov ID: NCT04765137
What this study is testing
What is Atorvastatin Oral Tablet?
Atorvastatin Oral Tablet is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for mild cognitive impairment.
Also referred to as Lipitor oral tablet.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this study is to evaluate the effect of atorvastatin on brain vessel reactivity and with it on blood flow in people with mild cognitive impairment.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 60 to 95. Healthy volunteers may be eligible.
You may be able to join if
- are chosen to include participants with MCI, enriched for vascular risk factors:
- MCI defined by Clinical Dementia Rating (CDR) of 0.5 or 1.0.
- Memory, processing speed, executive function, language - cognitive scores \> 1.5 standard deviations below age-education norms.
- Not demented by history.
- Not taking statins currently or in the last 6 months.
You likely can't join if
- Taking a statin currently or have taken a statin in the last 6 months.
- Contraindications to taking a statin.
- Transplant patient taking cyclosporine.
- Unable to undergo MRI procedures (such as having an implanted pacemaker or defibrillator or stimulator or having non MRI compatible metal).
- Diagnosis of dementia by history.
- Current diagnosis of substance abuse.
See the full eligibility criteria
- are chosen to include participants with MCI, enriched for vascular risk factors:
- MCI defined by Clinical Dementia Rating (CDR) of 0.5 or 1.0.
- Memory, processing speed, executive function, language - cognitive scores \> 1.5 standard deviations below age-education norms.
- Not demented by history.
- Not taking statins currently or in the last 6 months.
- Cognitive/functional impairment not likely due to another neurological disease or delirium.
- Taking a statin currently or have taken a statin in the last 6 months.
- Contraindications to taking a statin.
- Transplant patient taking cyclosporine.
- Unable to undergo MRI procedures (such as having an implanted pacemaker or defibrillator or stimulator or having non MRI compatible metal).
- Diagnosis of dementia by history.
- Current diagnosis of substance abuse.
- History of stroke or myocardial infarction in past 6 months.
- History of HIV.
The study team makes the final eligibility decision.
Where it's taking place
- Baltimore, Maryland, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 60 years to 95 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Baltimore, Maryland, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.